CAJ | 학술논문

文章以丙烯酸（AA）、甲基丙烯酸（MAA）、丙酸（PA）、乙酸（HOAc）、氯乙酸（CA）为模型分子，研究了小分子氢键给体对羟丙甲基纤维素（HPMC）在水中的低临界溶解温度（lower critical solution temperature ， LCST ）的影响。研究发现LCST与小分子氢键供体的质量分数呈反比关系，进一步研究表明，LCST 的变化率与小分子的分子面积、分子体积、羧基的电负性及脂水分配系数（lg P）有密切的关系。
문장이병희산（AA）、갑기병희산（MAA）、병산（PA）、을산（HOAc）、록을산（CA）위모형분자，연구료소분자경건급체대간병갑기섬유소（HPMC）재수중적저림계용해온도（lower critical solution temperature ， LCST ）적영향。연구발현LCST여소분자경건공체적질량분수정반비관계，진일보연구표명，LCST 적변화솔여소분자적분자면적、분자체적、최기적전부성급지수분배계수（lg P）유밀절적관계。
In this paper ,acrylic acid(AA) ,methacrylic acid(MAA) ,propionic acid(PA) ,acetic acid (HOAc) ,chloroacetic acid(CA) were used as model molecules to study the influence of small mole‐cule hydrogen‐bond donor on the lower critical solution temperature (LCST ) of hydroxypropyl methyl cellulose(HPMC) in aqueous solution .It is found that the LCST and the concentration of small mole‐cules hydrogen‐bond donor exhibit inversely proportional relationship .Further studies show that the rate of change of the LCST has close relationship with molecular area ,molecular volume ,carboxyl group electronegativity and lipid‐water partition coefficient (lg P) of these small molecules .