CAJ | 학술논문

目的：探讨右美托咪定对于预防肝移植术后早期精神异常的疗效及安全性。方法采用随机对照研究，将160例肝移植术后患者以抽签法随机分为两组各80例，分别应用右美托咪定治疗和咪达唑仑进行治疗组，比较两组患者的一般情况、精神异常发生率及不良反应发生情况。结果两组患者的的一般情况（性别、年龄、术后应用呼吸机时间、ICU 住院日、手术时间、术后 FK506血药浓度、术后24小时 APACHE II 评分）差异无统计学意义（P ＞0．05），术后精神异常发生率观察组20．00％，低于对照组38．75％（P ＝0．009），不良反应观察组低血压及高血压发生率高于对照组（P ＝0．035，P ＝0．029）。结论右美托咪定用于肝移植术后早期患者，可有效降低术后精神异常的发生。
목적：탐토우미탁미정대우예방간이식술후조기정신이상적료효급안전성。방법채용수궤대조연구，장160례간이식술후환자이추첨법수궤분위량조각80례，분별응용우미탁미정치료화미체서륜진행치료조，비교량조환자적일반정황、정신이상발생솔급불량반응발생정황。결과량조환자적적일반정황（성별、년령、술후응용호흡궤시간、ICU 주원일、수술시간、술후 FK506혈약농도、술후24소시 APACHE II 평분）차이무통계학의의（P ＞0．05），술후정신이상발생솔관찰조20．00％，저우대조조38．75％（P ＝0．009），불량반응관찰조저혈압급고혈압발생솔고우대조조（P ＝0．035，P ＝0．029）。결론우미탁미정용우간이식술후조기환자，가유효강저술후정신이상적발생。
Objective To investigate effects and safety of dexmedetomidine on the prevention of abnormal mental in patients after liver transplantation.Methods 160 patients after liver transplantation were randomly divided into the two groups using the drawing method:midazolam group(n =80),dexmedetomidine group(n =80),compared the two groups of patients with general,mental abnormality and the occurrence of adverse reactions.Results There were no significant differences in the general situation (gender,age,postoperative ventilator time,ICU stay time,oper-ation time,blood FK506 concentration,APACHEII score 24 hours after operation)of the two groups of patients (P >0.05),the spirit of the abnormal rate of the observation group was lower than that of the control group (P =0.009), incidence of hypotension and hypertension in the observation group was higher than that in the control group (P =0.035,0.029).Conclusion Dexmedetomidine can effectively reduce the postoperative mental disorders in patients in the early stage after liver transplantation.