CAJ | 학술논문

目的：探讨2型糖尿病患者的无症状糖尿病周围神经病(ADPN)神经电生理损害的相关因素，为临床早期诊断、早期干预提供依据。方法176例2型糖尿病患者根据有无神经传导速度异常分为ADPN组(32例)和No-DPN组(144例)，对比分析相关临床资料并探讨ADPN神经电生理损害的相关因素。结果单因素分析显示：ADPN组糖尿病病程、体质指数、空腹血糖、糖化血红蛋白、尿素氮、肌酐、24 h尿蛋白和尿微量白蛋白、眼底动脉血管改变与No-DPN组比较，差异有统计学意义(P<0.05)；多因素Logistic回归分析显示：糖尿病病程、体质指数、空腹血糖、糖化血红蛋白是ADPN神经电生理损害的独立相关因素。结论神经传导速度测定可作为ADPN的早期诊断依据，病程、体质指数、空腹血糖、糖化血红蛋白与ADPN密切相关，应尽早诊断与干预。
목적：탐토2형당뇨병환자적무증상당뇨병주위신경병(ADPN)신경전생리손해적상관인소，위림상조기진단、조기간예제공의거。방법176례2형당뇨병환자근거유무신경전도속도이상분위ADPN조(32례)화No-DPN조(144례)，대비분석상관림상자료병탐토ADPN신경전생리손해적상관인소。결과단인소분석현시：ADPN조당뇨병병정、체질지수、공복혈당、당화혈홍단백、뇨소담、기항、24 h뇨단백화뇨미량백단백、안저동맥혈관개변여No-DPN조비교，차이유통계학의의(P<0.05)；다인소Logistic회귀분석현시：당뇨병병정、체질지수、공복혈당、당화혈홍단백시ADPN신경전생리손해적독립상관인소。결론신경전도속도측정가작위ADPN적조기진단의거，병정、체질지수、공복혈당、당화혈홍단백여ADPN밀절상관，응진조진단여간예。
Aim To explore relevant related factors with asymptomatic peripheral neuropathy of diabetic mellitus patients type 2 and provide the basis for early diagnosis and intervention.Methods 176 patients of diabetic type 2 were divided into a asymptomatic diabetic peripheral neuropathy (ADPN) group (144 cases) and a non-diabetes peripheral neuropathy (No-DPN) group (32 cases) according to nerve conduction velocity in electromyography exam. Clinical data of the two groups were comparably analyzed to investigate the related factors involving with asymptomatic peripheral neuropathy in diabetic patients. ResultsIndividual factors of diabetes duration, fasting blood glucose (FBG), body mass index (BMI), hemoglobin A (HbA1c), blood urine nitrogen (BUN), creatinine (Cr), 24 h proteinuria quantity, 24 h urinary microalbumin amount and positive ifndings from fundus examination were signiifcantly related with ADPN inducing from the single factor analysis. Logistic regression analysis showed the duration of diabetes, FBG, BMI and HbA1C were independent of the related factors in ADPN.ConclusionDiabetes duration, FBG, BMI and HbA1C can be independent of the related factors involving with ADPN based on nerve conduction velocity in which should be early diagnosed and intervened by physician.