CAJ | 학술논문

目的：探讨帕金森病(PD)冻结步态的临床及多巴胺转运体显像特征。方法选取复旦大学附属华山医院PD数据库中的30例原发性PD患者，分为冻结步态(FOG+)组(11例)和无冻结步态(FOG-)组(19例)。分别对两组患者进行11C-CFT-DAT显像和临床运动评分，对11C-CFT-DAT显像结果与临床运动评分进行相关性分析。结果 FOG+组尾状核的纹状体不对称指数(SAI)显著增高(P=0.004)；UPDRS运动评分与重侧(受累严重肢体对侧)尾状核与前壳核比值呈正相关(P=0.034)；NFOGQ评分与重侧尾状核SAI呈负相关(P=0.020)；冻结步态与尾状核SAI呈显著负相关(P=0.028)。结论双侧尾状核不对称性损害是导致PD患者冻结步态的重要原因，冻结步态可能是皮质-纹状体-脑干-躯体通路中不对称性损害的结果。
목적：탐토파금삼병(PD)동결보태적림상급다파알전운체현상특정。방법선취복단대학부속화산의원PD수거고중적30례원발성PD환자，분위동결보태(FOG+)조(11례)화무동결보태(FOG-)조(19례)。분별대량조환자진행11C-CFT-DAT현상화림상운동평분，대11C-CFT-DAT현상결과여림상운동평분진행상관성분석。결과 FOG+조미상핵적문상체불대칭지수(SAI)현저증고(P=0.004)；UPDRS운동평분여중측(수루엄중지체대측)미상핵여전각핵비치정정상관(P=0.034)；NFOGQ평분여중측미상핵SAI정부상관(P=0.020)；동결보태여미상핵SAI정현저부상관(P=0.028)。결론쌍측미상핵불대칭성손해시도치PD환자동결보태적중요원인，동결보태가능시피질-문상체-뇌간-구체통로중불대칭성손해적결과。
AimTo investigate the characteristics in the Parkinson’s disease (PD) patients with freezing of gait (FOG) by clinical rating and11C-CFT-DAT imaging.MethodsClinical characteristics and11C-CFT uptake were compared between FOG+ and FOG, and their correlation were evaluated.Results Striatal asymmetry index (SAI) of11C-CFT uptake was statistically in creased in caudate nucleus when compared with the FOG subjects. On the other hand, SAI in caudate was negatively correlated with scores of NFOGQ and posture.ConclusionAsymmetric disruption in caudate nuleus, a key component of cortical-striatum-pons-body system, may play an essential role in the mechanism of freezing of gait.