中国临床神经科学
中國臨床神經科學
중국림상신경과학
CHINESE JOURNAL OF CLINICAL NEUROSCIENCES
2015年
3期
287-291
,共5页
毛仁玲%钟平%徐健%徐铭%江澄川
毛仁玲%鐘平%徐健%徐銘%江澄川
모인령%종평%서건%서명%강징천
脑膜瘤%脊索瘤型脑膜瘤%颅内%细胞增殖标记物%预后
腦膜瘤%脊索瘤型腦膜瘤%顱內%細胞增殖標記物%預後
뇌막류%척색류형뇌막류%로내%세포증식표기물%예후
meningioma%chordoid meningioma%intracranial%MIB-1%prognosis
目的:探讨脊索瘤型脑膜瘤的临床、病理特征及预后特点。方法回顾性分析22例行手术切除并经病理证实为脊索瘤型脑膜瘤患者的临床资料,应用相应抗体重新染色标记并进行临床疗效随访。结果22例患者中,男性9例、女性13例;平均年龄46.5岁。均未见明确有Castleman综合征表现;病变均系单发,多数位于小脑幕上。病理检查示脊索样基质占20%~80%,淋巴细胞浸润以B细胞为主,细胞增殖标记物(MIB-1)标记指数为2%~10%,平均2.5%。19例患者达全切,3例患者达次全切除。所有患者均获随访,平均随访时间44.0个月,4例患者复发;次全切除与复发相关;复发患者MIB-1标记指数与非复发患者比较差异无统计学意义。结论脊索瘤型脑膜瘤是非典型脑膜瘤的一个少见亚型,具有复发风险,女性略多见;患者缺乏明确的系统性疾病表现,小脑幕上是好发部位,手术切除程度与患者预后相关,MIB-1标记指数预测复发的意义尚难肯定。
目的:探討脊索瘤型腦膜瘤的臨床、病理特徵及預後特點。方法迴顧性分析22例行手術切除併經病理證實為脊索瘤型腦膜瘤患者的臨床資料,應用相應抗體重新染色標記併進行臨床療效隨訪。結果22例患者中,男性9例、女性13例;平均年齡46.5歲。均未見明確有Castleman綜閤徵錶現;病變均繫單髮,多數位于小腦幕上。病理檢查示脊索樣基質佔20%~80%,淋巴細胞浸潤以B細胞為主,細胞增殖標記物(MIB-1)標記指數為2%~10%,平均2.5%。19例患者達全切,3例患者達次全切除。所有患者均穫隨訪,平均隨訪時間44.0箇月,4例患者複髮;次全切除與複髮相關;複髮患者MIB-1標記指數與非複髮患者比較差異無統計學意義。結論脊索瘤型腦膜瘤是非典型腦膜瘤的一箇少見亞型,具有複髮風險,女性略多見;患者缺乏明確的繫統性疾病錶現,小腦幕上是好髮部位,手術切除程度與患者預後相關,MIB-1標記指數預測複髮的意義尚難肯定。
목적:탐토척색류형뇌막류적림상、병리특정급예후특점。방법회고성분석22례행수술절제병경병리증실위척색류형뇌막류환자적림상자료,응용상응항체중신염색표기병진행림상료효수방。결과22례환자중,남성9례、녀성13례;평균년령46.5세。균미견명학유Castleman종합정표현;병변균계단발,다수위우소뇌막상。병리검사시척색양기질점20%~80%,림파세포침윤이B세포위주,세포증식표기물(MIB-1)표기지수위2%~10%,평균2.5%。19례환자체전절,3례환자체차전절제。소유환자균획수방,평균수방시간44.0개월,4례환자복발;차전절제여복발상관;복발환자MIB-1표기지수여비복발환자비교차이무통계학의의。결론척색류형뇌막류시비전형뇌막류적일개소견아형,구유복발풍험,녀성략다견;환자결핍명학적계통성질병표현,소뇌막상시호발부위,수술절제정도여환자예후상관,MIB-1표기지수예측복발적의의상난긍정。
Aim To discuss the clinicopathological aspects and prognosis of chordoid meningioma (CM) at a single institute.MethodsThe clinical data of the patients with 22 CMs were retrieved from the records of our department. The specimens were stained with hematoxylin-eosin (H-E). Immunohistochemistry for epithelial membrane antigen (EMA), vimentin, glial fibrillary acidic protein (GFAP), leucocyte common antigen (LCA), CD3, CD10, CD20, CK and S-100 were done and MIB-1 labeling index (MIB-1 LI) was calculated in all cases. The patients’ prognosis was attained by clinic service and telephone interview. ResultsThe 22 patients included 9 males and 13 females with a mean age of 46.5 years old. No systemic manifestations of Castleman’s syndrome were found. The majority of tumors were in the supratentorial compartments. Chordoid elements comprised 20% to 80% of the entire tumor area. The lymphocytic inifltrate was predominantly of B-cell. The MIB-1 LI varied from 2% to 10% (mean 2.5%). The 22 cases included 19 cases for total removal and 3 cases for subtotal removal. Among all 22 patients had follow-up with the mean follow-up period of 44.0 months. Four patients recurred. Subtotal resection was associated with recurrence. The MIB-1 LI did not show signiifcant difference between the patients with recurrence and the patients without recurrence (P>0.05).Conclusion CM is a rare subtype of meningioma of adults with a risk of recurrence. There is a slight female preponderance in the subtype. There is absence of systemic manifestations and connection with Castleman’s syndrome. Supratentorial location is the most preferred location. Immunohistochemistry is helpful to differentiate CM from other primary tumors. The extent of resection might likely predict the recurrence.