CAJ | 학술논문

四环素类抗生素以其突出的抗菌性能和较低的副作用而被广泛用于细菌感染疾病的治疗和控制，污水处理系统作为环境中四环素类抗生素及其抗性基因的一个重要污染点源，已引起广泛关注。尽管如此，目前关于四环素类抗生素在污水处理过程中的降解行为及影响因子，及其对降解微生物抗药性的选择性效应方面的研究还较少。在分析总结国内外四环素类抗生素污染现状基础上，对污水处理过程中四环素类抗生素的去除行为及影响因素等进行分析，探讨了其抗性基因在污水处理过程中的污染特征，同时分析了四环素类抗生素对其抗性基因的诱导、演变和传播的影响，并对今后的研究发展方向进行了展望，以期为从污水处理系统达到控制和去除四环素类抗生素及其抗性基因提供方向和依据。
사배소류항생소이기돌출적항균성능화교저적부작용이피엄범용우세균감염질병적치료화공제，오수처리계통작위배경중사배소류항생소급기항성기인적일개중요오염점원，이인기엄범관주。진관여차，목전관우사배소류항생소재오수처리과정중적강해행위급영향인자，급기대강해미생물항약성적선택성효응방면적연구환교소。재분석총결국내외사배소류항생소오염현상기출상，대오수처리과정중사배소류항생소적거제행위급영향인소등진행분석，탐토료기항성기인재오수처리과정중적오염특정，동시분석료사배소류항생소대기항성기인적유도、연변화전파적영향，병대금후적연구발전방향진행료전망，이기위종오수처리계통체도공제화거제사배소류항생소급기항성기인제공방향화의거。
Tetracycline antibiotics have been widely administered to treat and control diseases due to their effective antimicrobial actions and the lack of major side effects. The sewage treatment plants have attracted much attention as one of the main point-sources of pollution with respect to tetracycline antibiotics and tetracycline resistance genes. However,only few studies were focusing on the degradation behavior of tetracycline antibiotics during sewage treatment process and the pressure selection on their corresponding resistance genes. Based on the summary of pollution situati on of tetracycline antibiotics,their removal behavior and relevant influencing factors during sewage treatment process were analyzed. The pollution characteristics of tetracycline resistance genes were investigated. In addition,the effects of tetracycline antibiotics on the induction,evolution and spread of tetracycline resistance genes were discussed. Finally,the future research directions in this area were suggested. The aim of this review is to provide the direction and evidence for the removal of tetracycline antibiotics and tetracycline resistance genes in sewage treatment systems.