CAJ | 학술논문

目的：观察注射用丁二磺酸腺苷蛋氨酸结合丁二磺酸腺苷蛋氨酸肠溶片治疗肝内胆汁淤积的临床效果。方法90例肝内胆汁淤积患者，将其随机分为三组，每组30例。单用注射用丁二磺酸腺苷蛋氨酸为注射组，单用丁二磺酸腺苷蛋氨酸肠溶片为口服组，两药同时应用为结合组，对比并分析各组的治疗效果。结果治疗后所有患者血清总胆红素(TBIL)、结合胆红素(DBIL)、谷丙转氨酶(ALT)和谷草转氨酶(AST)水平均明显下降(P<0.05)，结合组下降最为显著，其与注射组及口服组比较，差异有统计学意义(P<0.05)；结合组治疗后临床疗效优于注射组和口服组(P<0.05)。结论注射用丁二磺酸腺苷蛋氨酸结合丁二磺酸腺苷蛋氨酸肠溶片治疗肝内胆汁淤积的效果要优于单一用药，值得在临床中广泛应用。
목적：관찰주사용정이광산선감단안산결합정이광산선감단안산장용편치료간내담즙어적적림상효과。방법90례간내담즙어적환자，장기수궤분위삼조，매조30례。단용주사용정이광산선감단안산위주사조，단용정이광산선감단안산장용편위구복조，량약동시응용위결합조，대비병분석각조적치료효과。결과치료후소유환자혈청총담홍소(TBIL)、결합담홍소(DBIL)、곡병전안매(ALT)화곡초전안매(AST)수평균명현하강(P<0.05)，결합조하강최위현저，기여주사조급구복조비교，차이유통계학의의(P<0.05)；결합조치료후림상료효우우주사조화구복조(P<0.05)。결론주사용정이광산선감단안산결합정이광산선감단안산장용편치료간내담즙어적적효과요우우단일용약，치득재림상중엄범응용。
Objective To observe the clinical effect of ademetionine 1,4-butanedisulfonate for injection combined with ademetionine 1,4-butanedisulfonate enteric-coated tablet in the treatment of intrahepatic cholestasis.Methods A total of 90 patients with intrahepatic cholestasis were randomly divided into three groups, with 30 cases in each group. Injection group received single treatment by ademetionine 1,4-butanedisulfonate for injection, oral administration group received ademetionine 1,4-butanedisulfonate enteric-coated tablet for treatment, and combined group received combined treatment by the two drugs. Curative effects of three groups were compared and analyzed.Results After treatment, all patients had decreased levels of total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) (P<0.05). The combined group had the most huge decrease, and its difference with injection group and oral administration group had statistical significance (P<0.05). The combined group also had better clinical effect after treatment than the injection group and the oral administration group (P<0.05).Conclusion Combination of ademetionine 1,4-butanedisulfonate for injection and ademetionine 1,4-butanedisulfonate enteric-coated tablet provides better effect in treating intrahepatic cholestasis than single drug treatment. This method is worthy of widely clinical application.