CAJ | 학술논문

目的：观察急诊经皮冠状动脉介入治疗(PCI)术前联合应用替格瑞洛与替罗非班的疗效和安全性。方法105例行急诊PCI术的急性ST段抬高型心肌梗死(STEMI)患者随机分为观察组(54例)和对照组(51例)，术前均给予静脉滴注替罗非班，其中观察组联合应用替格瑞洛，对照组联合应用氯吡格雷。观察并比较两组患者术前及术后90 min心电图ST段抬高回落率， PCI治疗前后梗死相关动脉(IRA)的血流TIMI分级及PCI术后的TIMI心肌灌注分级(TMPG)。结果观察组ST段回落明显，罪犯血管TIMI分级及心肌再灌注分级均高于对照组，差异有统计学意义(P<0.05)。结论急诊PCI术前联合应用替格瑞洛与替罗非班能够显著改善心肌灌注，具有更好的临床效果且安全性较高。
목적：관찰급진경피관상동맥개입치료(PCI)술전연합응용체격서락여체라비반적료효화안전성。방법105례행급진PCI술적급성ST단태고형심기경사(STEMI)환자수궤분위관찰조(54례)화대조조(51례)，술전균급여정맥적주체라비반，기중관찰조연합응용체격서락，대조조연합응용록필격뢰。관찰병비교량조환자술전급술후90 min심전도ST단태고회락솔， PCI치료전후경사상관동맥(IRA)적혈류TIMI분급급PCI술후적TIMI심기관주분급(TMPG)。결과관찰조ST단회락명현，죄범혈관TIMI분급급심기재관주분급균고우대조조，차이유통계학의의(P<0.05)。결론급진PCI술전연합응용체격서락여체라비반능구현저개선심기관주，구유경호적림상효과차안전성교고。
Objective To observe the curative effect and safety of combined ticagrelor and tirofiban before emergency percutaneous coronary intervention (PCI).Methods A total of 105 with ST-segment elevation myocardial infarction (STEMI) under emergency PCI were randomly divided into observation group (54 cases) and control group (51 cases). They all received preoperative tirofiban through intravenous drip, and the observation group received combined drug with ticagrelor, while the control group received combined drug with clopidogrel. Observation and comparison were made on electrocardiogram ST-segment elevation and drop rate before operation and after 90 min of operation, blood TIMI grad of infarction related artery(IRA) before and after PCI, and TIMI myocardial perfusion grade (TMPG) after PCI of the two groups.Results The observation group had obvious drop of ST-segment, and its culprit vessel TIMI grade and TMPG were all higher than the control group. Their difference had statistical significance (P<0.05).Conclusion Combination of ticagrelor and tirofiban before emergency PCI can remarkably improve myocardial perfusion, with good clinical effect and high safety.