中国急救医学
中國急救醫學
중국급구의학
CHINESE JOURNAL OF CRITICAL CARE MEDICINE
2015年
6期
526-529
,共4页
尾加压素Ⅱ( U-Ⅱ)%神经激肽B( NKB)%急性心肌梗死( AMI)%冠心病( CAD)
尾加壓素Ⅱ( U-Ⅱ)%神經激肽B( NKB)%急性心肌梗死( AMI)%冠心病( CAD)
미가압소Ⅱ( U-Ⅱ)%신경격태B( NKB)%급성심기경사( AMI)%관심병( CAD)
UrotensinⅡ( U-Ⅱ)%Neurokinin B(NKB)%Acute myocardial infarction(AMI)%Coronary artery disease( CAD)
目的：观察急性心肌梗死（ AMI）和稳定型冠心病（ CAD）患者血清尾加压素Ⅱ（ urotensin－Ⅱ， U－Ⅱ）和神经激肽B（ neurokinin B， NKB）变化情况，评价这些变化与相关疾病发生机制的联系。方法本试验是前瞻性病例对照研究，入院患者随机分成三组：AMI组（ n＝64）、CAD组（n＝64）和对照组（n＝62）。检测相关生化参数、U－Ⅱ及NKB。采用K－S方法评价数据正态性分布，采用单因素方差分析比较三组间数据。结果与对照组和稳定型CAD组比较， AMI组患者血清U－Ⅱ、NKB水平显著降低（P＜0．005），且具有相关性（r＝0．720，P＝0．000）。血清U－Ⅱ、NKB与左心室射血分数（ LVEF）相关性较差，与C－反应蛋白（ CRP）没有相关性。结论 AMI组患者U－Ⅱ和NKB水平降低与动脉粥样硬化具有相关性。
目的：觀察急性心肌梗死（ AMI）和穩定型冠心病（ CAD）患者血清尾加壓素Ⅱ（ urotensin－Ⅱ， U－Ⅱ）和神經激肽B（ neurokinin B， NKB）變化情況，評價這些變化與相關疾病髮生機製的聯繫。方法本試驗是前瞻性病例對照研究，入院患者隨機分成三組：AMI組（ n＝64）、CAD組（n＝64）和對照組（n＝62）。檢測相關生化參數、U－Ⅱ及NKB。採用K－S方法評價數據正態性分佈，採用單因素方差分析比較三組間數據。結果與對照組和穩定型CAD組比較， AMI組患者血清U－Ⅱ、NKB水平顯著降低（P＜0．005），且具有相關性（r＝0．720，P＝0．000）。血清U－Ⅱ、NKB與左心室射血分數（ LVEF）相關性較差，與C－反應蛋白（ CRP）沒有相關性。結論 AMI組患者U－Ⅱ和NKB水平降低與動脈粥樣硬化具有相關性。
목적：관찰급성심기경사（ AMI）화은정형관심병（ CAD）환자혈청미가압소Ⅱ（ urotensin－Ⅱ， U－Ⅱ）화신경격태B（ neurokinin B， NKB）변화정황，평개저사변화여상관질병발생궤제적련계。방법본시험시전첨성병례대조연구，입원환자수궤분성삼조：AMI조（ n＝64）、CAD조（n＝64）화대조조（n＝62）。검측상관생화삼수、U－Ⅱ급NKB。채용K－S방법평개수거정태성분포，채용단인소방차분석비교삼조간수거。결과여대조조화은정형CAD조비교， AMI조환자혈청U－Ⅱ、NKB수평현저강저（P＜0．005），차구유상관성（r＝0．720，P＝0．000）。혈청U－Ⅱ、NKB여좌심실사혈분수（ LVEF）상관성교차，여C－반응단백（ CRP）몰유상관성。결론 AMI조환자U－Ⅱ화NKB수평강저여동맥죽양경화구유상관성。
Objective This study aims to investigate whether there are possible plasma urotensin-II ( U -II ) and neurokinin B ( NKB ) level changes in patients with acute myocardial infarction (AMI) and coronary artery disease (CAD) and to evaluate whether there is any relationship between these changes and the pathogenesis of these diseases.Methods This is a prospective case-control study.Three groups were formed from randomly admitted patients with AMI(n=64), CAD(n=64) and controls ( n =62 ) .Biochemical parameters and U -Ⅱ and NKB levels were measured by biochemistry analyzer.The normality of the data was evaluated using the Kolmogorov-Smirnov test.We compared the three groups with one-way ANOVA and Tukey test ( Kruskal-Wallis test and Mann-Whitney U test) .Results Compared with controls and CAD patients, AMI patients had lower U-Ⅱand NKB levels (P <0.005).In cases of CAD, U -Ⅱ and NKB levels were similar.A positive correlation was found between U-Ⅱand NKB (r=0.720, P=0.000).U-Ⅱ and NKB were poorly correlated with left ventricle ejection fraction but not with C-reactive protein.Conclusion U-Ⅱand NKB levels are lower in patients with AMI in than those with CAD or the control.The decreased U-Ⅱand NKB levels are related to complicated atherosclerotic events.
