CAJ | 학술논문

目的：分析万古霉素联合替考拉宁治疗重症革兰氏阳性菌感染的临床效果及评价。方法搜集本院2014年1月～2015年1月收治的46例革兰氏阳性菌感染的重症患者，随机分为两组，21例对照组给予单纯万古霉素药物，25例研究组给予万古霉素与替考拉宁联合药物，对比两组疗效。结果两组疗效比较，研究组治疗总有效率为92.0%、细菌清除率为88.0%、不良反应的发生率为8%优于对照组81.0%、71.4%、23.8%，P＜0.05,差异具有统计学意义。结论万古霉素联合替考拉宁治疗重症革兰氏阳性菌感染的疗效显著，患者的治疗效果好，细菌感染清除率高、用药安全性也高，临床应用价值极高。
목적：분석만고매소연합체고랍저치료중증혁란씨양성균감염적림상효과급평개。방법수집본원2014년1월～2015년1월수치적46례혁란씨양성균감염적중증환자，수궤분위량조，21례대조조급여단순만고매소약물，25례연구조급여만고매소여체고랍저연합약물，대비량조료효。결과량조료효비교，연구조치료총유효솔위92.0%、세균청제솔위88.0%、불량반응적발생솔위8%우우대조조81.0%、71.4%、23.8%，P＜0.05,차이구유통계학의의。결론만고매소연합체고랍저치료중증혁란씨양성균감염적료효현저，환자적치료효과호，세균감염청제솔고、용약안전성야고，림상응용개치겁고。
Objective Clinical effect and evaluation on Vancomycin combine with Teicoplanin medication in treatment of severe Gram-positive bacteria infection. Methods Selected 46 patients infected with severe Gram-positive bacteria that were treated in hospital from January 2014 to January 2015 and separate them into two groups at random, 21 patients in control group were given Vancomycin medication treatment only, while 25 patients in study group were given Vancomycin combined with Teicoplanin medication treatment and then compared treatment effects between two groups. Results Patients’ treatment efficacy in study group was 92.0%, bacteria cleansing rate was up to 88.0% and side-effect incidence was 8%, which are much better than counterparts of 81.0%, 71.4%and 23.8%in control, P<0.05,had difference statistically significance. Conclusion Vancomycin combined with Teicoplanin medication is of efficacy in treatment of severe Gram-positive bacteria infection; it is conducive to increasing bacteria cleansing rate with medication safety, thus, such a medication treatment is of great application value.