CAJ | 학술논문

目的：研究不同年龄阶段月经正常的生育期妇女抗苗勒管激素（AMH）水平的变化，了解AMH与年龄的关系及其在预测卵巢衰老中的价值。方法选择2012年12月至2014年7月在嘉兴市妇幼保健院行健康体检的月经正常的1423例生育期妇女，按年龄阶段分为：≤25岁、26～30岁、31～35岁、36～40岁、≥41岁，检测其血清AMH水平，并分析与年龄的关系。结果≤25岁、26～30岁、31～35岁、36～40岁、≥41岁妇女的血清AMH水平中位数分别为3.62、3.10、2.27、1.07、0.45μg/L；不同年龄阶段妇女血清AMH水平比较，差异有统计学意义（H=232.386，P<0.01）。血清AMH水平与年龄呈负相关（r=－0.374，P<0.01）；血清AMH水平在25岁后即开始下降，36岁后下降明显。logAMH （即AMH的对数）的二次回归拟合最佳地反映了AMH与年龄的关系。结论检测生育期妇女血清AMH水平可早期预示卵巢功能的下降，可作为预警卵巢衰老的指标。
목적：연구불동년령계단월경정상적생육기부녀항묘륵관격소（AMH）수평적변화，료해AMH여년령적관계급기재예측란소쇠로중적개치。방법선택2012년12월지2014년7월재가흥시부유보건원행건강체검적월경정상적1423례생육기부녀，안년령계단분위：≤25세、26～30세、31～35세、36～40세、≥41세，검측기혈청AMH수평，병분석여년령적관계。결과≤25세、26～30세、31～35세、36～40세、≥41세부녀적혈청AMH수평중위수분별위3.62、3.10、2.27、1.07、0.45μg/L；불동년령계단부녀혈청AMH수평비교，차이유통계학의의（H=232.386，P<0.01）。혈청AMH수평여년령정부상관（r=－0.374，P<0.01）；혈청AMH수평재25세후즉개시하강，36세후하강명현。logAMH （즉AMH적대수）적이차회귀의합최가지반영료AMH여년령적관계。결론검측생육기부녀혈청AMH수평가조기예시란소공능적하강，가작위예경란소쇠로적지표。
Objective To explore the serum anti-Mullerian hormone (AMH) level in women of childbearing age with normal menstrual cycles. Methods A total of 1 423 women with regular menstrual cycles were selected and divided into 5 groups according to their ages, i.e.≤25, 26-30, 31-35, 36-40,≥41 years. Their serum levels of AMH were measured, and the relationship between AMH and age was analyzed. Results The serum AMH levels of 5 groups according to ages (≤25, 26-30, 31-35, 36-40, ≥41 years) were 3.62, 3.10, 2.27, 1.07, 0.45μg/L, respectively. The comparison of serum AMH levels in different age groups had significant difference (P<0.01). Serum AMH level declined with increasing age,and dropped significantly after 36. The serum AMH level and age showed a negative correlation with significant difference (r=-0.374, P<0.01). Quadratic regression of logAMH proximally reflected the relationship between AMH and age. Conclusion AMH determination for women of childbearing age could provide reference for the evaluation of ovarian function.