CAJ | 학술논문

病毒性心肌炎的发病机制目前尚未完全明了,涉及到病毒对心肌细胞的直接损害、病毒诱发的自身免疫反应、基因多态性和遗传易患性等多个方面,其症状轻重不一,预后亦有很大差异.该文综述柯萨奇-腺病毒受体、维生素D受体、人类白细胞抗原、一氧化氮合酶、基质金属蛋白酶、血管紧张素转换酶和各种细胞因子的基因多态性与病毒性心肌炎的关系,以期对病毒性心肌炎的预防与诊治提供新的思路.
병독성심기염적발병궤제목전상미완전명료,섭급도병독대심기세포적직접손해、병독유발적자신면역반응、기인다태성화유전역환성등다개방면,기증상경중불일,예후역유흔대차이.해문종술가살기-선병독수체、유생소D수체、인류백세포항원、일양화담합매、기질금속단백매、혈관긴장소전환매화각충세포인자적기인다태성여병독성심기염적관계,이기대병독성심기염적예방여진치제공신적사로.
The pathogenesis of viral myocarditis(VMC)still remains uncertain.The direct viral damage to heart muscle cells,the autoimmunity induced by viruses,the gene polymorphism and the genentic susceptibility are involved.Moreover,the symptoms and the prognosis of VMC are various.The relationship between VMC and the relevant gene polymorphism are reviewed in this paper,including coxsackie-adenovirus receptor,vitamin D receptor,human leukocyte antigen,nitric oxide synthase,matrix metalloproteinases,angiotensin converting enzyme and various cytokine.The purpose is to find new breakthroughs on VMC prevention and treatment.