CAJ | 학술논문

目的：探讨P504s在胰腺实性假乳头瘤（SPTP）和胰腺神经内分泌肿瘤（PanNET）鉴别诊断中的作用。方法收集2007年至2014年确诊的43例SPTP、41例PanNET病例，采用免疫组织化学EnVision方法观察波形蛋白、CD10、嗜铬粒素A、突触素、β-catenin、CD99、P504s等多项免疫组织化学抗体在两组肿瘤中的表达情况，重点阐述P504s的鉴别诊断中的作用。结果波形蛋白、CD10、嗜铬粒素A、突触素、CD99等免疫标志物在这两组织肿瘤中都有不同程度的表达，P504s在所有SPTP中呈胞质颗粒状阳性表达，所有PanNET肿瘤均不表达P504s。结论 P504s对SPTP的诊断具有敏感性，是鉴别SPTP和PanNET一个有价值的免疫标记指标。
목적：탐토P504s재이선실성가유두류（SPTP）화이선신경내분비종류（PanNET）감별진단중적작용。방법수집2007년지2014년학진적43례SPTP、41례PanNET병례，채용면역조직화학EnVision방법관찰파형단백、CD10、기락립소A、돌촉소、β-catenin、CD99、P504s등다항면역조직화학항체재량조종류중적표체정황，중점천술P504s적감별진단중적작용。결과파형단백、CD10、기락립소A、돌촉소、CD99등면역표지물재저량조직종류중도유불동정도적표체，P504s재소유SPTP중정포질과립상양성표체，소유PanNET종류균불표체P504s。결론 P504s대SPTP적진단구유민감성，시감별SPTP화PanNET일개유개치적면역표기지표。
Objective To study the significance of P504s in differential diagnosis between solid pseudopapillary tumor of the pancreas(SPTP) and pancreatic neuroendocrine tumors(PanNET).Methods Forty-three patients with SPTP and 41 patients with PanNET encountered during the period from 2007 to 2014 were recruited.Immunohistochemical study for vimentin, CD10, chromogranin A, synaptophysin, beta-catenin, CD99 and P504s in SPTP and PanNET was performed.The diagnostic value of P504s in differentiating SPTP from PanNET was analyzed. Results Immunohistochemical study showed that vimentin, CD10, chromogranin A, synaptophysin and CD99 were expressed both in SPTP and PanNET.All cases of SPTP showed granular cytoplasmic expression of P504s, whereas those of PanNET were negative. Conclusion P504s is a sensitive and useful marker for SPTP and can be used in the distinction between SPTP and PanNET.