针灸临床杂志
針灸臨床雜誌
침구림상잡지
JOURNAL OF CLINICAL ACUPUNCTURE AND MOXIBUSTION
2015年
5期
61-64
,共4页
贾坤平%孙忠人%尹洪娜%勇入琳%张建奇%侯二雷%吴磊
賈坤平%孫忠人%尹洪娜%勇入琳%張建奇%侯二雷%吳磊
가곤평%손충인%윤홍나%용입림%장건기%후이뢰%오뢰
艾灸%预处理%大椎%发热%IL-6%大鼠
艾灸%預處理%大椎%髮熱%IL-6%大鼠
애구%예처리%대추%발열%IL-6%대서
Moxibustion%Pretreatment%Dazhui%Fever%IL-6%Rats
目的：通过观察艾灸预处理大椎穴对酵母菌诱导大鼠发热模型的影响，揭示艾灸的退热机制及艾灸预处理的作用。方法：从40只Wistar大鼠中以随机数字表法随机抽出8只作为空白组，再随机抽出8只大鼠进行艾灸预处理并做好标记，为艾灸预处理组。艾灸预处理结束后将除空白组以外的32只大鼠分别采用20％干酵母混悬液皮下注射造模，造模成功后，将剩余的符合条件的24只大鼠随机分为模型组、艾灸组、安痛定组，每组8只。艾灸组及艾灸预处理组分别予以艾灸大椎穴治疗15 min，安痛定组予以腹腔注射安痛定治疗，分别测量造模前、造模后8h及治疗后1h、2h、3h、4h各时间点体温并于实验结束后分别测量各组大鼠血清IL－6含量。结果：艾灸组、安痛定组、艾灸预处理组与模型组比较均有显著性差异（P＜0．01），艾灸组与安痛定组、艾灸预处理组比较均有显著性差异（P＜0．01），而安痛定组与艾灸预处理组比较无显著性差异（P＞0．05），且与空白组比较均无显著性差异（P＞0．05）。结论：艾灸具有一定的解热作用，艾灸预处理具有降低热势的功效，其作用机制可能为通过抑制血清IL－6生成或对抗其作用，进而减少内生致热源对体温调节中枢的影响，使体温调定点上移幅度减低或恢复正常，从而达到降低热势及退热的作用。
目的：通過觀察艾灸預處理大椎穴對酵母菌誘導大鼠髮熱模型的影響，揭示艾灸的退熱機製及艾灸預處理的作用。方法：從40隻Wistar大鼠中以隨機數字錶法隨機抽齣8隻作為空白組，再隨機抽齣8隻大鼠進行艾灸預處理併做好標記，為艾灸預處理組。艾灸預處理結束後將除空白組以外的32隻大鼠分彆採用20％榦酵母混懸液皮下註射造模，造模成功後，將剩餘的符閤條件的24隻大鼠隨機分為模型組、艾灸組、安痛定組，每組8隻。艾灸組及艾灸預處理組分彆予以艾灸大椎穴治療15 min，安痛定組予以腹腔註射安痛定治療，分彆測量造模前、造模後8h及治療後1h、2h、3h、4h各時間點體溫併于實驗結束後分彆測量各組大鼠血清IL－6含量。結果：艾灸組、安痛定組、艾灸預處理組與模型組比較均有顯著性差異（P＜0．01），艾灸組與安痛定組、艾灸預處理組比較均有顯著性差異（P＜0．01），而安痛定組與艾灸預處理組比較無顯著性差異（P＞0．05），且與空白組比較均無顯著性差異（P＞0．05）。結論：艾灸具有一定的解熱作用，艾灸預處理具有降低熱勢的功效，其作用機製可能為通過抑製血清IL－6生成或對抗其作用，進而減少內生緻熱源對體溫調節中樞的影響，使體溫調定點上移幅度減低或恢複正常，從而達到降低熱勢及退熱的作用。
목적：통과관찰애구예처리대추혈대효모균유도대서발열모형적영향，게시애구적퇴열궤제급애구예처리적작용。방법：종40지Wistar대서중이수궤수자표법수궤추출8지작위공백조，재수궤추출8지대서진행애구예처리병주호표기，위애구예처리조。애구예처리결속후장제공백조이외적32지대서분별채용20％간효모혼현액피하주사조모，조모성공후，장잉여적부합조건적24지대서수궤분위모형조、애구조、안통정조，매조8지。애구조급애구예처리조분별여이애구대추혈치료15 min，안통정조여이복강주사안통정치료，분별측량조모전、조모후8h급치료후1h、2h、3h、4h각시간점체온병우실험결속후분별측량각조대서혈청IL－6함량。결과：애구조、안통정조、애구예처리조여모형조비교균유현저성차이（P＜0．01），애구조여안통정조、애구예처리조비교균유현저성차이（P＜0．01），이안통정조여애구예처리조비교무현저성차이（P＞0．05），차여공백조비교균무현저성차이（P＞0．05）。결론：애구구유일정적해열작용，애구예처리구유강저열세적공효，기작용궤제가능위통과억제혈청IL－6생성혹대항기작용，진이감소내생치열원대체온조절중추적영향，사체온조정점상이폭도감저혹회복정상，종이체도강저열세급퇴열적작용。
Objective:To observe the effect of moxibustion pretreatment at Dazhui on fever rat models induced by yeast,and to reveal the defervescence mechanism of moxibustion and moxibustion pretreatment.Methods:Randomly select 8 rats from 40 Wistar rats as a blank group, and then randomly select other 8 rats for moxibus-tion pretreatment and make marks as a moxibustion pretreatment group.After moxibustion pretreatment, except the blank group, 20%dry yeast suspension was used respectively to 32 rats with subcutaneous injection.After the success of establishing the remaining, equally group qualified 24 rats into a model group, a moxibustion group and an Antondin group.Moxibustion group and moxibustion pretreatment group respectively were treated by moxibustion at Dazhui for 15 min, and the Antondin group was treated by intraperitoneal injection of An-tondin.Then measure the temperature before building models and after building 8 h and after treatment 1 h, 2 h, 3 h, 4 h.At the end of the experiment measure the serum IL-6 of each rat.Results:Compared with the model group,the moxibustion group,the Antondin group,the moxibustion pretreatment group had a significant difference ( P<0.01) .Compared with the moxibustion group,the Antondin group and the moxibustion pretreat-ment group had a significant difference ( P <0 .01 ) .The Antondin group and the moxibustion pretreatment group had no significant difference ( P>0 .05 ) , and compared with the blank group there was no significant difference ( P>0.05 ) .Conclusion:Moxibustion has certain antipyretic effect.The effect of moxibustion pre-treatment can reduce thermal potential.Its mechanism may be generated by inhibiting the serum IL-6 or its role, then reducing the influence of the temperature regulating center by endogenous pyrogens,to reduce temper-ature set-point up amplitude or return to normal, so as to reduce the thermal potential and have an antipyretic effect.
