CAJ | 학술논문

目的：探讨精神分裂症患者血清蛋白因子浓度与认知功能之间的相关性。方法采用酶联免疫吸技术（ELISA）测定46例精神分裂症患者（研究组）和50名正常对照者（对照组）血清中3个蛋白因子的浓度，应用精神分裂症认知功能成套测验共识版（MCCB）进行认知功能评估。结果研究组 NGF-β低于对照组（P ＜0．01），而 IL-1β、MBP浓度高于对照组（P ＜0．01）。研究组 MCCB 检测中 TMT 评分高于对照组（P ＜0．01），BACS SC、HVLT-R、WMS-III SS、NAB、BVMT-R、CF 评分低于对照组（P ＜0．01）。研究组血清蛋白 IL-1β浓度与 BACS SC 评分呈负相关（P ＜0．01）；血清蛋白 MBP 浓度与 WMS-III SS 评分呈负相关（P ＜0．01）。结论精神分裂症患者的认知功能障碍可能与血清蛋白因子浓度存在关联性，精神分裂症可能存在中枢神经的损害或退化。
목적：탐토정신분렬증환자혈청단백인자농도여인지공능지간적상관성。방법채용매련면역흡기술（ELISA）측정46례정신분렬증환자（연구조）화50명정상대조자（대조조）혈청중3개단백인자적농도，응용정신분렬증인지공능성투측험공식판（MCCB）진행인지공능평고。결과연구조 NGF-β저우대조조（P ＜0．01），이 IL-1β、MBP농도고우대조조（P ＜0．01）。연구조 MCCB 검측중 TMT 평분고우대조조（P ＜0．01），BACS SC、HVLT-R、WMS-III SS、NAB、BVMT-R、CF 평분저우대조조（P ＜0．01）。연구조혈청단백 IL-1β농도여 BACS SC 평분정부상관（P ＜0．01）；혈청단백 MBP 농도여 WMS-III SS 평분정부상관（P ＜0．01）。결론정신분렬증환자적인지공능장애가능여혈청단백인자농도존재관련성，정신분렬증가능존재중추신경적손해혹퇴화。
Objective To investigate the relationship between serum level of protein factors and cognitive dysfunction in patients with schizophrenia.Methods The serum level of three protein factors were measured with ELISA in 46 patients with schizophrenia (study group)and 50 healthy controls (control group).The MATRICS consensus cognitive battery (MCCB)was used to assess the cognitive function.Results The serum level of NGF-βin study group was significantly lower than that in control group (P <0.01),while serum level of IL-1βand MBP in study group were significantly higher than those in control group (P <0.01).Score of TMT in MCCB in study group was significantly higher than that in control group (P <0.01),while scores of BACS SC,HVLT-R,WMS-III SS,NAB,BVMT-R and CF in MCCB in study group was significantly lower than those in control group (P <0.01).Serum level of IL-1βin study group was significantly negatively correlated with score of BACS SC (P <0.01 ),and serum level of BMP in study group was significantly negatively correlated with score of WMS-III SS (P <0.01).Conclusion Cognitive dysfunction in patients with schizophrenia may be related with level of serum protein factors, which suggests that central nerve lesion or degradation may be involved in the etiology of schizophrenia.