CAJ | 학술논문

目的：探讨多囊卵巢综合征（PCOS）患者瘦素、血清脂联素与胰岛素抵抗水平间的相关性。方法：选择PC O S患者120例为观察组，同时随机选取体检健康、月经正常的120例妇女为对照组，两组均行常规指标、瘦素、脂联素与胰岛素抵抗的检测与相关性分析。结果：两组的体重指数、腰臀围、收缩压、舒张压对比差异无统计学意义（P＞0．05）。与对照组相比，观察组的空腹胰岛素与胰岛素抵抗值明显较高（P＜0．05）；两组空腹血糖值对比，差异无统计学意义（P＞0．05）。观察组的血清脂联素明显低于对照组，而血清瘦素值明显高于对照组，对比差异都有统计学意义（P＜0．05）。Pearson相关性分析显示胰岛素抵抗与瘦素值呈现明显正相关性，与脂联素呈现明显负相关性，而瘦素与脂联素也呈现明显负相关性（P＜0．05）。结论：PCOS患者多存在瘦素、血清脂联素与胰岛素抵抗水平的异常，其中血清高瘦素与低脂联素水平可导致胰岛素抵抗，三者之间存在明显的相关性。
목적：탐토다낭란소종합정（PCOS）환자수소、혈청지련소여이도소저항수평간적상관성。방법：선택PC O S환자120례위관찰조，동시수궤선취체검건강、월경정상적120례부녀위대조조，량조균행상규지표、수소、지련소여이도소저항적검측여상관성분석。결과：량조적체중지수、요둔위、수축압、서장압대비차이무통계학의의（P＞0．05）。여대조조상비，관찰조적공복이도소여이도소저항치명현교고（P＜0．05）；량조공복혈당치대비，차이무통계학의의（P＞0．05）。관찰조적혈청지련소명현저우대조조，이혈청수소치명현고우대조조，대비차이도유통계학의의（P＜0．05）。Pearson상관성분석현시이도소저항여수소치정현명현정상관성，여지련소정현명현부상관성，이수소여지련소야정현명현부상관성（P＜0．05）。결론：PCOS환자다존재수소、혈청지련소여이도소저항수평적이상，기중혈청고수소여저지련소수평가도치이도소저항，삼자지간존재명현적상관성。
Objective:To investigate the correlation of leptin ,adiponectin and insulin resistance levels in thepatientswithpolycysticovarysyndrome.Methods:Selected 120polycysticovarysyndromepatientsfromJuly 2011 to February 2014 in our hospital as the observation group ,while selected physical health normal menstruation 120 women as the control group ,both groups were given the conventional index ,leptin ,adiponectin and insulin re‐sistance detected and correlation analyzed .Results:The BMI ,waist hip circumference ,systolic and diastolic blood pressure compared between the two groups were no statistically significant differences (P>0 .05) .The fasting insu‐lin and insulin resistance values of the observation group were significantly higher (P<0 .05) ,and the fasting blood glucose levels compared between the two groups showed no significant difference (P>0 .05) .The serum adiponectin levels of the observation group were significantly lower than that in control group ,and the serum leptin levels were significantly higher (P<0 .05) .Pearson correlation analysis showed that insulin resistance were positive correlated with the leptin values ,and were showed significant negative correlated to the adiponectin ,whereas leptin and adi‐ponectin also showed the significant negative correlation (P<0 .05) .Conclusion :Polycystic ovary syndrome patients are more combined with abnormal leptin ,adiponectin and insulin resistance levels ,the high serum leptin and adi‐ponectin levels can lead to insulin resistance ,there is clear correlation among the three indexs .