CAJ | 학술논문

目的：筛选一种对粪肠球菌有抑菌效能的纳米羟磷灰石复合材料。方法选用载银纳米羟磷灰石（Ag/nHA）、载钇纳米羟磷灰石（Yi/nHA）、载铈纳米羟磷灰石（Ce/nHA）、普通纳米羟磷灰石（nHA）为实验材料，分别采用琼脂扩散法和琼脂稀释法，通过计量不同实验材料对粪肠球菌的抑菌环直径和最小抑菌浓度（MIC），评价4种纳米复合材料对粪肠球菌的影响。结果琼脂扩散法显示Ag/nHA周围出现明显的抑菌环，而Yi/nHA、Ce/nHA、nHA周围均无抑菌环。琼脂稀释法显示Ag/nHA对粪肠球菌的MIC为1.0?g·L-1；其他材料即使浓度高达32.0?g·L-1也未表现出抑制粪肠球菌的作用。结论 Ag/nHA对浮游状态的粪肠球菌有较好的抑制作用，而Yi/nHA、Ce/nHA、nHA在实验浓度范围内均无明显地抑制粪肠球菌的作用。
목적：사선일충대분장구균유억균효능적납미간린회석복합재료。방법선용재은납미간린회석（Ag/nHA）、재을납미간린회석（Yi/nHA）、재시납미간린회석（Ce/nHA）、보통납미간린회석（nHA）위실험재료，분별채용경지확산법화경지희석법，통과계량불동실험재료대분장구균적억균배직경화최소억균농도（MIC），평개4충납미복합재료대분장구균적영향。결과경지확산법현시Ag/nHA주위출현명현적억균배，이Yi/nHA、Ce/nHA、nHA주위균무억균배。경지희석법현시Ag/nHA대분장구균적MIC위1.0?g·L-1；기타재료즉사농도고체32.0?g·L-1야미표현출억제분장구균적작용。결론 Ag/nHA대부유상태적분장구균유교호적억제작용，이Yi/nHA、Ce/nHA、nHA재실험농도범위내균무명현지억제분장구균적작용。
ObjectiveThis?study?aims?to?compare?and?determine?a?kind?of?nano-hydroxyapatite?composite?material?with?good?antibacterial?efficacy?on?Enterococcus faecalis(E. faecalis)?in vitro.?Methods???We?investigated?the?antimicrobial?acti-vity?of?four?kinds?of?nano-hydroxyapatite?composites,?namely,?silver/hydroxyapatite?composite?nanoparticles?(Ag/nHA),?yttrium/hydroxyapatite?composite?nanoparticles?(Yi/nHA),?cerium/hydroxyapatite?composite?nanoparticles?(Ce/nHA),?and?hydroxyapatite?nanoparticles?(nHA),?against?E. faecalis?in vitro?using?the?agar?diffusion?and?broth?dilution?method?by?mea-suring?the?growth?inhibition?zone?and?the?minimum?inhibitory?concentration?(MIC),?respectively.?Results???The?agar?diffu-sion?test?results?showed?that?Ag/nHA?displayed?an?obvious?growth?inhibition?zone,?whereas?Yi/nHA,?Ce/nHA,?and?nHA?showed?no?influence?on?E. faecalis.?The?MIC?value?of?Ag/nHA?was?1.0?g·L-1,?and?the?three?other?materials?had?no?effect?on?E. faecalis?even?at?the?high?concentration?of?32.0?g·L-1.?Conclusion???Ag/nHA?display?a?potential?antimicrobial?efficacy?to?planktonic?E. faecalis.?Whereas,?the?three?other?kinds?of?nano-hydroxyapatite?composites?(Yi/nHA,?Ce/nHA,?nHA)?show?no?influence.