CAJ | 학술논문

目的回顾性研究尸检病例中前列腺的病理特点,探讨前列腺慢性炎症与其他病变的相关性。方法随机选择40例前列腺癌及40例非前列腺尸检前列腺标本,观察前列腺标本的组织病理学特征。结果80例尸检病例中有前列腺慢性炎症的为76例(95.0%),有前列腺结节状增生为62例(77.5%),有局灶性萎缩的为62例(77.5%)。前列腺癌与前列腺炎症、炎症程度、前列腺结节状增生、前列腺局灶性萎缩及萎缩的类型均无相关性(P>0.05)。与是否伴有前列腺高分级上皮内瘤(high grade prostatic introepithe鄄lial neoplasia,HGPIN)有相关性,7例HGPIN均发生于前列腺癌组(P<0.05)。局灶性萎缩中有8例萎缩后增生,其与HGPIN呈正相关(P<0.05)；但有无萎缩后增生与前列腺癌无相关性(P>0.05)。结论前列腺炎、前列腺结节状增生及前列腺局灶性萎缩与前列腺癌发病无相关性,但萎缩后增生与HGPIN呈正相关, HGPIN与前列腺腺癌呈正相关,因此认为萎缩后增生是一种前列腺癌的癌前病变。
목적회고성연구시검병례중전렬선적병리특점,탐토전렬선만성염증여기타병변적상관성。방법수궤선택40례전렬선암급40례비전렬선시검전렬선표본,관찰전렬선표본적조직병이학특정。결과80례시검병례중유전렬선만성염증적위76례(95.0%),유전렬선결절상증생위62례(77.5%),유국조성위축적위62례(77.5%)。전렬선암여전렬선염증、염증정도、전렬선결절상증생、전렬선국조성위축급위축적류형균무상관성(P>0.05)。여시부반유전렬선고분급상피내류(high grade prostatic introepithe견lial neoplasia,HGPIN)유상관성,7례HGPIN균발생우전렬선암조(P<0.05)。국조성위축중유8례위축후증생,기여HGPIN정정상관(P<0.05)；단유무위축후증생여전렬선암무상관성(P>0.05)。결론전렬선염、전렬선결절상증생급전렬선국조성위축여전렬선암발병무상관성,단위축후증생여HGPIN정정상관, HGPIN여전렬선선암정정상관,인차인위위축후증생시일충전렬선암적암전병변。
Objective To study the correlation between prostatic chronic inflammation and other related lesions by retrospective review of the pathological features in autopsies. Method random selecting 40 cases of prostate carcino-ma and 40 cases of non-prostate carcinoma, observing the histopathologic features of the prostatic samples. Result There are 76 cases with prostatic chronic inflammation in 80 autopsy cases (95. 0%), and 62 cases with prostatic focal atrophy (77. 5%). There are no correlations between prostatic carcinomas and prostatic inflammation, prostat-ic nodular hyperplasia, focal atrophy, and subtypes of focal atrophy (P>0. 05). There is correlation between pros-tatic carcinomas and HGPIN, and all of HGPINs happen in the group of prostatic carcinomas(P<0. 05). There are 8 cases of postatrophic hyperplasia in focal atrophy, and there is positive correlation between postatrophic hyperpla-sia and HGPIN(P<0. 05), and there is no correlation between postatrophic hyperplasia and prostatic carcinoma (P>0. 05). Conclusion There are no direct correlation between prostatic carcinomas and prostatic inflammation, prostatic nodular hyperplasia, and focal atrophy. There are positive correlation between postatrophic hyperplasia and HGPIN, and positive correlation between HGPIN and prostatic carcinomas. Therefore, we think that postatrophic hyperplasia is a precancerous lesion.