中国医刊
中國醫刊
중국의간
CHINESE JOURNAL OF MEDICINE
2015年
6期
24-27
,共4页
高尿酸血症%早期糖尿病肾病%2型糖尿病%微量白蛋白尿
高尿痠血癥%早期糖尿病腎病%2型糖尿病%微量白蛋白尿
고뇨산혈증%조기당뇨병신병%2형당뇨병%미량백단백뇨
Hyperuricemia%The early stage of diabetic nephropathy%Type 2 diabetes%Microalbuminuria
目的探讨尿酸与早期糖尿病肾病之间的关系。方法以住院的2型糖尿病患者为研究对象。测定患者的体重指数( body mass index,BMI)、血压、肝肾功能、空腹血糖、血脂、血尿酸、糖化血红蛋白( gly鄄cated hemoglobin A1c,HbA1c)、尿微量白蛋白( urinary albumin excretion rate,UAER)等相关临床指标。根据UAER水平的不同分为两组：早期糖尿病肾病组( DN组),20μg/min<UAER<200μg/min,共172例；糖尿病正常尿白蛋白组( DM组),UAER<20μg/min,共156例。比较两组临床检测指标,运用统计学方法分析糖尿病肾病与尿酸及其他指标之间的关系。结果DN组的糖尿病病程、HbA1c、空腹血糖、甘油三酯( triglyceride, TG)、血清总胆固醇( serum total cholesterol,TC)、低密度脂蛋白( low density lipoprotein,LDL)、UAER水平明显高于DM组,而高密度脂蛋白(high density lipoprotein,HDL)低于DM组(P<0.05)；UAER水平与糖尿病病程、HbA1c、空腹血糖、血尿酸、TC、TG、LDL、收缩压呈正相关,而与HDL呈负相关。进行多元回归分析,糖尿病病程、糖化血红蛋白、血尿酸、TG、TC、HDL、收缩压进入最后的回归方程。按UAER是否升高、有无高尿酸血症(男性≥420μmol/L,女性≥360μmol/L)形成四格表进行字2检验,字2=5.537,P=0.019。结论高尿酸血症是2型糖尿病患者早期糖尿病肾病的一项危险因素。
目的探討尿痠與早期糖尿病腎病之間的關繫。方法以住院的2型糖尿病患者為研究對象。測定患者的體重指數( body mass index,BMI)、血壓、肝腎功能、空腹血糖、血脂、血尿痠、糖化血紅蛋白( gly鄄cated hemoglobin A1c,HbA1c)、尿微量白蛋白( urinary albumin excretion rate,UAER)等相關臨床指標。根據UAER水平的不同分為兩組：早期糖尿病腎病組( DN組),20μg/min<UAER<200μg/min,共172例；糖尿病正常尿白蛋白組( DM組),UAER<20μg/min,共156例。比較兩組臨床檢測指標,運用統計學方法分析糖尿病腎病與尿痠及其他指標之間的關繫。結果DN組的糖尿病病程、HbA1c、空腹血糖、甘油三酯( triglyceride, TG)、血清總膽固醇( serum total cholesterol,TC)、低密度脂蛋白( low density lipoprotein,LDL)、UAER水平明顯高于DM組,而高密度脂蛋白(high density lipoprotein,HDL)低于DM組(P<0.05)；UAER水平與糖尿病病程、HbA1c、空腹血糖、血尿痠、TC、TG、LDL、收縮壓呈正相關,而與HDL呈負相關。進行多元迴歸分析,糖尿病病程、糖化血紅蛋白、血尿痠、TG、TC、HDL、收縮壓進入最後的迴歸方程。按UAER是否升高、有無高尿痠血癥(男性≥420μmol/L,女性≥360μmol/L)形成四格錶進行字2檢驗,字2=5.537,P=0.019。結論高尿痠血癥是2型糖尿病患者早期糖尿病腎病的一項危險因素。
목적탐토뇨산여조기당뇨병신병지간적관계。방법이주원적2형당뇨병환자위연구대상。측정환자적체중지수( body mass index,BMI)、혈압、간신공능、공복혈당、혈지、혈뇨산、당화혈홍단백( gly견cated hemoglobin A1c,HbA1c)、뇨미량백단백( urinary albumin excretion rate,UAER)등상관림상지표。근거UAER수평적불동분위량조：조기당뇨병신병조( DN조),20μg/min<UAER<200μg/min,공172례；당뇨병정상뇨백단백조( DM조),UAER<20μg/min,공156례。비교량조림상검측지표,운용통계학방법분석당뇨병신병여뇨산급기타지표지간적관계。결과DN조적당뇨병병정、HbA1c、공복혈당、감유삼지( triglyceride, TG)、혈청총담고순( serum total cholesterol,TC)、저밀도지단백( low density lipoprotein,LDL)、UAER수평명현고우DM조,이고밀도지단백(high density lipoprotein,HDL)저우DM조(P<0.05)；UAER수평여당뇨병병정、HbA1c、공복혈당、혈뇨산、TC、TG、LDL、수축압정정상관,이여HDL정부상관。진행다원회귀분석,당뇨병병정、당화혈홍단백、혈뇨산、TG、TC、HDL、수축압진입최후적회귀방정。안UAER시부승고、유무고뇨산혈증(남성≥420μmol/L,녀성≥360μmol/L)형성사격표진행자2검험,자2=5.537,P=0.019。결론고뇨산혈증시2형당뇨병환자조기당뇨병신병적일항위험인소。
Objective To discuss the relationship between serum uric acid and the early stage of diabetic nephropa-thy. Method The hospitalized patients with type 2 diabetes were studied and body mass index( BMI)、blood pres-sure、serum creatinine、fasting blood glucose, lipids, serum unci acid、urinary albumin excretion rates( UAER) were measured and calculated. The patients were divided into two groups based on the level of UAER:DN group included those whose UAER>20μg/min but<200μg/min (172 patients),while in DM group, UAER<20μg/min(156 pa-tients) . The characteristics and clinical items were compared, and the relationship between serum uric acid and UAER was statistical analyzed. Result The duration of diabetes、HbA1C、fasting blood glucose、triglyceride (TG), serum total cholesterol( TC) , low density lipoprotein ( LDL) and UAER were significantly higher in DN group than in DM group, while high density lipoprotein ( HDL) in DN group was evidently lower than in DM group. The level of UAER was positively correlated with duration of diabetes、HbA1C、fasting blood glucose、uric acid、TC、TG、LDL and systolic blood pressure, but negatively correlated with HDL. After multivariate regression, duration of diabetes、HbA1C、serum uric acid、TG、TC、HDL and systolic blood pressure emerged the final regression equation. All pa-tients were redevised into crosstab based on the levels of UARE and serum uric acid ( hyperuricemia, male≥420μmol/L, female≥360μmol/L),the data of Chi square test showed that the value of Chi square was 5. 537,P=0. 019. Conclusion Hyperuricemia is a risk factor of the early stage of diabetic nephropathy in type 2 diabetes.
