陕西中医
陝西中醫
협서중의
SHAANXI JOURNAL OF TRADITIONAL CHINESE MEDICINE
2015年
6期
732-734
,共3页
黄芪甲苷%星点设计-效应面法%玄七通痹胶囊
黃芪甲苷%星點設計-效應麵法%玄七通痺膠囊
황기갑감%성점설계-효응면법%현칠통비효낭
Astragaloside%Central composite design-responsesurface method%Xuanqi Tongbi capsule
目的：采用星点设计‐效应面法优选玄七通痹胶囊中黄芪甲苷含量测定的色谱条件。方法：以乙腈与水的比例，蒸发室温度和氮气的流速为考察因素，以峰面积、分离度、对称度为考察指标，进行总评归一化，并进行多元线性回归和二项式拟合，用效应面法选择较佳工艺条件，并进行预测分析。结果：确定黄芪甲苷的色谱条件为乙腈‐水33：67，蒸发室温度为90℃，氮气流速为1．4 SLM 。结论：星点设计‐效应面法优选玄七通痹胶囊中黄芪甲苷含量测定的色谱条件，方法简便，预测性良好。
目的：採用星點設計‐效應麵法優選玄七通痺膠囊中黃芪甲苷含量測定的色譜條件。方法：以乙腈與水的比例，蒸髮室溫度和氮氣的流速為攷察因素，以峰麵積、分離度、對稱度為攷察指標，進行總評歸一化，併進行多元線性迴歸和二項式擬閤，用效應麵法選擇較佳工藝條件，併進行預測分析。結果：確定黃芪甲苷的色譜條件為乙腈‐水33：67，蒸髮室溫度為90℃，氮氣流速為1．4 SLM 。結論：星點設計‐效應麵法優選玄七通痺膠囊中黃芪甲苷含量測定的色譜條件，方法簡便，預測性良好。
목적：채용성점설계‐효응면법우선현칠통비효낭중황기갑감함량측정적색보조건。방법：이을정여수적비례，증발실온도화담기적류속위고찰인소，이봉면적、분리도、대칭도위고찰지표，진행총평귀일화，병진행다원선성회귀화이항식의합，용효응면법선택교가공예조건，병진행예측분석。결과：학정황기갑감적색보조건위을정‐수33：67，증발실온도위90℃，담기류속위1．4 SLM 。결론：성점설계‐효응면법우선현칠통비효낭중황기갑감함량측정적색보조건，방법간편，예측성량호。
Objective:Use central composite design‐response surface method to prefer HPLC chromatographic conditions of astragaloside content from Xuanqi Tongbi capsule .Methods :Three factors were the acetonitrile ,water ratio the temperature of evaporation room and the flow rate of nitrogen ,to study the peak area ,seperation and symmetry as in‐dicators after overall normalization ,multiple linear regression and binomial fitting with response surface method to choose the better process conditions ,and predictive analysis .Results :The chromatographic conditions for the determination of astragaloside were the acetonitrile‐water 33 :67 ,evaporation room temperature was 90 ℃ ,the flow rate of nitrogen was 1 .4 SLM .Conclusion:It shows that the optimum model is highly predictive .
