CAJ | 학술논문

目的：分析中药注射剂引起重要器官药源性损害的发生率及影响因素。方法检索1993－2013年中国医院知识总库(CHKD)、万方数据知识平台有关中药注射剂药物不良反应和药源性疾病的个案报道。建立指标体系，对相关内容进行统计分析。结果在检索的文献中有34种中药注射剂发生药源性疾病，涉及699例患者，占总不良反应比例53.98%，其中排名前3位的中药注射剂依次是刺五加注射液、红花注射液和脉络宁注射液。文献中，中药注射剂产生药源性疾病的主要原因为溶媒选择不合理，配伍浓度过大，用法用量与说明书不符。结论中药注射剂引起重要器官的药源性损害的发生率较高，在临床使用中应严格按照药品说明书内容操作。
목적：분석중약주사제인기중요기관약원성손해적발생솔급영향인소。방법검색1993－2013년중국의원지식총고(CHKD)、만방수거지식평태유관중약주사제약물불량반응화약원성질병적개안보도。건립지표체계，대상관내용진행통계분석。결과재검색적문헌중유34충중약주사제발생약원성질병，섭급699례환자，점총불량반응비례53.98%，기중배명전3위적중약주사제의차시자오가주사액、홍화주사액화맥락저주사액。문헌중，중약주사제산생약원성질병적주요원인위용매선택불합리，배오농도과대，용법용량여설명서불부。결론중약주사제인기중요기관적약원성손해적발생솔교고，재림상사용중응엄격안조약품설명서내용조작。
ObjectiveTo study the occurrence and influence factors of drug-induced injuries of vital organs caused by traditional Chinese medicine injection.MethodsChina Hospital Knowledge Database (CHKD) from 1993-2013 and case reports concerning adverse effects and drug-induced diseases caused by traditional Chinese medicine injection from Wanfang Data Knowledge Service Platformwere retrieved. Indicator systemwasestablished and relevant contentsweresummarized and analyzed.Results34 types of traditional Chinese medicine injectionswereincluded and 699 drug-induced diseasesweresummarized, taking up 53.98% of the total adverse effects. Among them, the top three included in the drug-induced diseaseswere acanthopanax injection, safflower injection and Mailuoning injection. The non-conformance between the traditional Chinese medicine injections in the literature and instructions mainly reflects unreasonable solvent selection, large compatibility concentration and usage and dosage beyond those specified in the instructions. ConclusionThe occurrence of drug-induced injuries of vital organs caused by traditional Chinese medicine injectionis relatively high, drug instructions shall be strictly followed in accordance with requirements during clinical application.