国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2015年
6期
494-497
,共4页
张艳景%吕素君%王培培%刘经选%郭娜
張豔景%呂素君%王培培%劉經選%郭娜
장염경%려소군%왕배배%류경선%곽나
肿瘤%抑郁症%抗抑郁药%中草药%甘麦大枣汤
腫瘤%抑鬱癥%抗抑鬱藥%中草藥%甘麥大棘湯
종류%억욱증%항억욱약%중초약%감맥대조탕
Neoplasms%Depression%Antidepressive agents%Drugs,Chinese herbal%Gan Mai Da Zao Tang
目的:评价加味甘麦大枣汤治疗恶性肿瘤相关性抑郁的临床疗效。方法本研究为随机对照研究。将符合纳入标准的98例患者按随机数字表法分为2组各49例,对照组在常规抗肿瘤治疗基础上配合服用氟哌噻吨美利曲辛片,治疗组在常规抗肿瘤治疗基础上加用甘麦大枣汤,共8周。采用汉密尔顿抑郁量表(Hamilton Depression Scale, HAMD)评价临床疗效。结果治疗组与对照组有效率分别为79.59%(39/49)、75.51%(37/49),2组比较差异无统计学意义(χ2=0.059,P=0.809)。治疗前后HAMD 评分治疗组[(29.4±4.7)分比(12.8±3.4)分,t=20.032]与对照组[(28.7±4.5)分比(12.3±3.6)分,t=19.921]均较同组治疗前明显降低(P<0.01),但2组治疗后HAMD评分比较,差异无统计学意义(t=0.707,P=0.481)。结论加味甘麦大枣汤为主治疗恶性肿瘤相关性抑郁与氟哌噻吨美利曲辛片疗效相当。
目的:評價加味甘麥大棘湯治療噁性腫瘤相關性抑鬱的臨床療效。方法本研究為隨機對照研究。將符閤納入標準的98例患者按隨機數字錶法分為2組各49例,對照組在常規抗腫瘤治療基礎上配閤服用氟哌噻噸美利麯辛片,治療組在常規抗腫瘤治療基礎上加用甘麥大棘湯,共8週。採用漢密爾頓抑鬱量錶(Hamilton Depression Scale, HAMD)評價臨床療效。結果治療組與對照組有效率分彆為79.59%(39/49)、75.51%(37/49),2組比較差異無統計學意義(χ2=0.059,P=0.809)。治療前後HAMD 評分治療組[(29.4±4.7)分比(12.8±3.4)分,t=20.032]與對照組[(28.7±4.5)分比(12.3±3.6)分,t=19.921]均較同組治療前明顯降低(P<0.01),但2組治療後HAMD評分比較,差異無統計學意義(t=0.707,P=0.481)。結論加味甘麥大棘湯為主治療噁性腫瘤相關性抑鬱與氟哌噻噸美利麯辛片療效相噹。
목적:평개가미감맥대조탕치료악성종류상관성억욱적림상료효。방법본연구위수궤대조연구。장부합납입표준적98례환자안수궤수자표법분위2조각49례,대조조재상규항종류치료기출상배합복용불고새둔미리곡신편,치료조재상규항종류치료기출상가용감맥대조탕,공8주。채용한밀이돈억욱량표(Hamilton Depression Scale, HAMD)평개림상료효。결과치료조여대조조유효솔분별위79.59%(39/49)、75.51%(37/49),2조비교차이무통계학의의(χ2=0.059,P=0.809)。치료전후HAMD 평분치료조[(29.4±4.7)분비(12.8±3.4)분,t=20.032]여대조조[(28.7±4.5)분비(12.3±3.6)분,t=19.921]균교동조치료전명현강저(P<0.01),단2조치료후HAMD평분비교,차이무통계학의의(t=0.707,P=0.481)。결론가미감맥대조탕위주치료악성종류상관성억욱여불고새둔미리곡신편료효상당。
ObjectiveTo evaluate the curative effect of supplementedGanmai-Dazaodecoction for malignant tumor correlation with depression.MethodsA total of 98 patients with malignant tumor-related depression were divided into a treatment group and acontrol group according to the random number table. The control group were treated with flupentixol and melitracen tablets (Deanxit) combined with conventional treatment, the treatment group were treated with oral administration of traditional Chinese medicine supplemented Ganmai-Dazaodecoction combined with conventional treatment for 8 weeks. The Hamilton Depression Scale (HAMD) was used to evaluate the curative effect.ResultsThe effective rate showed no significant difference between the treatment groupand the control group (79.59%vs.75.51%;χ2=0.059,P=0.809). HAMD scores in both groups were significantly decreased after the treatment than before treatment (12.8±3.4 vs. 29.4±4.7 in the treatment group, 12.3±3.6vs.28.7±4.5 in the controlgroup, allP<0.05), there was no significant difference in HAMD scores after the treatment between the treatment group and the control group (t=0.707,P=0.481). ConclusionCurative effect of supplementedGanmai-Dazaodecoction is equal to flupentixol andmelitracen tablets in patients with malignant tumor-related depression.