CAJ | 학술논문

目的：观察和分析血管性认知障碍（VCI）的各中医证型血管内皮功能及其智能情况。方法：将符合VCI诊断的患者进行辨证分型，分为肾虚髓减型、心肝阴虚型、心脾两虚型、痰浊阻窍型、气滞血瘀型，每型各收集30例，检测其血管内皮素‐1（ET‐1）、一氧化氮（NO）、超敏C反应蛋白（hs‐CRP）及简易智能精神状态量表（MMSE）并进行评分对比。结果：气滞血瘀型和痰浊阻窍型的ET‐1及hs‐CRP水平均较其余各组有所上升；肾虚髓减型、心肝阴虚型的NO水平与痰浊阻窍型、气滞血瘀型比较差异显著；气滞血瘀型和痰浊阻窍型的MMSE积分明显低于其余各型。结论：ET‐1、hs‐CRP水平与VCI的中医证型及认知功能损伤有一定关系，可作为VCI中医辨证的参考指标。
목적：관찰화분석혈관성인지장애（VCI）적각중의증형혈관내피공능급기지능정황。방법：장부합VCI진단적환자진행변증분형，분위신허수감형、심간음허형、심비량허형、담탁조규형、기체혈어형，매형각수집30례，검측기혈관내피소‐1（ET‐1）、일양화담（NO）、초민C반응단백（hs‐CRP）급간역지능정신상태량표（MMSE）병진행평분대비。결과：기체혈어형화담탁조규형적ET‐1급hs‐CRP수평균교기여각조유소상승；신허수감형、심간음허형적NO수평여담탁조규형、기체혈어형비교차이현저；기체혈어형화담탁조규형적MMSE적분명현저우기여각형。결론：ET‐1、hs‐CRP수평여VCI적중의증형급인지공능손상유일정관계，가작위VCI중의변증적삼고지표。
Objective:Observation and analysis of the endothelial function and intelligence between TCM syndrome types of vascular cognitive impairment(VCI) .Methods:We divided VCI patients with diagnosis of syndrome classifica‐tion into the shenxu suijian type ,xingan yinxu type ,xinpi liangxu type ,tanzhuo zuqiao type ,qizhi xueyu type ,each type to collect 30 cases ,tested its vascular endothelin 1 (ET‐1) ,nitric oxide (NO ) ,hypersensitive c‐reactive protein (hs‐CRP) and simple intelligent mental state scale (MMSE) score were compared .Results :The levels of ET‐1 and hs–CRP of qizhi xueyu type and tanzhuo zuqiao type were higher than the other types .The levels of shenxu suijian type and xingan yinxu type were observable different from tanzhuo zuqiao type and qizhi xueyu type .MMSE scores of tanzhuozuqiao type and qizhixueyu type significantly were lower than the other types .Conclusion:ET‐1 ,hs‐CRP levels have certain relations with TCM syndrome types of VCI and cognitie impairment .ET‐1 ,hs‐CRP can be used as a reference index between TCM syndrome types of the VCI .