CAJ | 학술논문

肺动脉高压(pulmonary artery hypertension,PAH)是各种原因引起的肺动脉压力持续升高的临床综合征,最终可导致右心衰竭以及死亡。微小 RNA(microRNAs,miRNAs)是真核细胞中一大类参与基因转录后调控的非编码小分子 RNA。miRNAs 通过参与 BMP/Smad 通路、Src/STAT3/Pim1通路、缺氧诱导因子-1α与 P53等信号通路的调控,影响 PAH 的发生发展。PAH 时,肺组织中某些miRNAs 表达可出现明显下调(miR-451和 miR-124等)或上调(miR-23b、miR-130a 和 miR-191等),可能是 PAH 的早期诊断生物标记物,对 miRNAs 与 PAH 的关系的深入研究可能为 PAH 的临床诊疗提供新的思路与靶点。
폐동맥고압(pulmonary artery hypertension,PAH)시각충원인인기적폐동맥압력지속승고적림상종합정,최종가도치우심쇠갈이급사망。미소 RNA(microRNAs,miRNAs)시진핵세포중일대류삼여기인전록후조공적비편마소분자 RNA。miRNAs 통과삼여 BMP/Smad 통로、Src/STAT3/Pim1통로、결양유도인자-1α여 P53등신호통로적조공,영향 PAH 적발생발전。PAH 시,폐조직중모사miRNAs 표체가출현명현하조(miR-451화 miR-124등)혹상조(miR-23b、miR-130a 화 miR-191등),가능시 PAH 적조기진단생물표기물,대 miRNAs 여 PAH 적관계적심입연구가능위 PAH 적림상진료제공신적사로여파점。
Pulmonary arterial hypertension (PAH ) is a debilitating disease characterized by progressive obstruction and obliteration of the pulmonary arteries ultimately leading to a progressive rise in pulmonary vascular resistance and right ventricular failure and death.MicroRNAs (miRNAs)are a class of small non-coding RNAs which involve in the regulation after gene transplantation.MiRNAs affect the development of PAH through participation in BMP/Smad pathway,Src/STAT3/Pim1 pathway, hypoxia-inducible factor-1α and P53 signaling pathway.Studies have shown that several novel downregulated miRNAs (miR-45 1,miR-124)and upregulated miRNAs (miR-23b,miR-130a and miR-1 91)appear in the circulation of PAH subjects.These miRNAs may be considered as potential biomarker for early diagnosis of PAH.Further investigation of the relationship between miRNAs and PAH will provide new ideas and targets for the diagnosis and treatment of PAH.