CAJ | 학술논문

一氧化氮作为非肾上腺能、非胆碱能神经的神经递质，可作用于血管并参与调节支气管平滑肌的功能。自从1993年 Alving 等首次发现呼出气一氧化氮(FeNO)在哮喘患者中明显升高，就开始了对 FeNO 的广泛研究。FeNO 测定作为一种评估伴有呼吸系统疾病的儿童气道炎症水平的非侵入性方法，目前已广泛应用于儿童哮喘的管理中。很多方法可以检测 FeNO 水平，尽管很多因素可以影响检测结果，但似乎它比肺功能及支气管激发试验有更高的准确性。目前 FeNO 在慢性咳嗽、ARDS、鼻炎、病毒性细支气管炎、社区获得性肺炎、支气管扩张、闭塞性细支气管炎及弥漫性肺疾病等儿童呼吸系统疾病的诊断、治疗及评估预后中也有很大的意义。
일양화담작위비신상선능、비담감능신경적신경체질，가작용우혈관병삼여조절지기관평활기적공능。자종1993년 Alving 등수차발현호출기일양화담(FeNO)재효천환자중명현승고，취개시료대 FeNO 적엄범연구。FeNO 측정작위일충평고반유호흡계통질병적인동기도염증수평적비침입성방법，목전이엄범응용우인동효천적관리중。흔다방법가이검측 FeNO 수평，진관흔다인소가이영향검측결과，단사호타비폐공능급지기관격발시험유경고적준학성。목전 FeNO 재만성해수、ARDS、비염、병독성세지기관염、사구획득성폐염、지기관확장、폐새성세지기관염급미만성폐질병등인동호흡계통질병적진단、치료급평고예후중야유흔대적의의。
As an neurotransmitter of non-adrenergic and non-cholinergic nerve,nitric oxide can act on blood vessels and involve in the regulation of bronchial smooth muscle function.Since Alving had firstly found in 1 993 that exhaled nitric oxide (FeNO)significantly increased in asthma patients,extensive study of FeNO present.As an non-invasive method,FeNO can be used to evaluate the airway inflammation of children who has respiratory disease and has been widely used in the management of childhood asthma. Many methods can detect FeNO levels,although many factors can affect the test results,but the FeNO seems to have a higher accuracy than pulmonary function and bronchial provocation tests.Currently FeNO also has great significance in the diagnosis,treatment and evaluation of prognosis of children′s respiratory disease such as chronic cough,acute respiratory distress syndrome,rhinitis,viral bronchiolitis,community acquired pneumonia,bronchiectasis,bronchiolitis obliterans and diffuse lung diseases.