CAJ | 학술논문

目的：分析总结极重度 COPD 稳定期联合应用福莫特罗粉/布地奈德及噻托溴铵治疗的临床价值。方法将100例 COPD 患者随机分为 A、B、C 3组,A 组34例,给予福莫特罗粉/布地奈德治疗；B 组33例,给予噻托溴铵治疗；C 组34例,给予联合福莫特罗粉/布地奈德及噻托溴铵治疗。对比3组临床治疗效果。结果3组接受治疗前 FEV1、FEV1/FVC、FEV1% pred 及圣乔治呼吸问卷(SGRQ)评分比较差异无统计学意义(P >0.05),但经治疗3个月后,3组 FEV1、FEV1/FVC、FEV1% pred 及SGRQ 比较差异有统计学意义(P <0.05),C 组明显优于 A 组及 B 组(P <0.05),而 A 组与 B 组比较,差异无统计学意义(P >0.05)；同时3组药物不良反应发生率比较,差异无统计学意义(P >0.05)。结论 COPD 稳定期患者联合应用福莫特罗粉/布地奈德及噻托溴铵治疗可在不增加药物不良反应的同时显著提高治疗效果。
목적：분석총결겁중도 COPD 은정기연합응용복막특라분/포지내덕급새탁추안치료적림상개치。방법장100례 COPD 환자수궤분위 A、B、C 3조,A 조34례,급여복막특라분/포지내덕치료；B 조33례,급여새탁추안치료；C 조34례,급여연합복막특라분/포지내덕급새탁추안치료。대비3조림상치료효과。결과3조접수치료전 FEV1、FEV1/FVC、FEV1% pred 급골교치호흡문권(SGRQ)평분비교차이무통계학의의(P >0.05),단경치료3개월후,3조 FEV1、FEV1/FVC、FEV1% pred 급SGRQ 비교차이유통계학의의(P <0.05),C 조명현우우 A 조급 B 조(P <0.05),이 A 조여 B 조비교,차이무통계학의의(P >0.05)；동시3조약물불량반응발생솔비교,차이무통계학의의(P >0.05)。결론 COPD 은정기환자연합응용복막특라분/포지내덕급새탁추안치료가재불증가약물불량반응적동시현저제고치료효과。
Objective Analysis summary very severe chronic obstructive pulmonary disease (COPD)plateau joint application f ROM mott powder/budesonide and consult the clinical value of bromide treatment.Methods One hundred COPD patients were randomly divided into A,B,C three groups,A group of 34 cases,giving Mr Mott powder/budesonide treatment,B group of 33 cases,give thiamethoxam bromide treatment,C group of 34 cases,gives the joint f ROM mott powder/budesonide and thiamethoxam bromide treatment.Compared three groups of clinical therapeutic effect.Results Three groups of treatment before the first second forced expiratory volume (FEV1 ),FEV1/FVC and forced vital capacity ratio,FEV1 percentage of predicted value (FEV1 %pred)and st George′s respiratory questionnaire score (SGRQ)is no statistical significance (P >0.05),but after 3 months treatment,the three groups of FEV1 ,FEV1/FVC,FEV1 %pred and SGRQ comparing statistical differences (P <0.05), group C is superior to group A and group B (P < 0.05 ),and group A and group B was no statistical difference (P >0.05).And three groups of drug side effects incidence is no statistical difference (P >0.05).Conclusions Patients with COPD stabilization combined use of f ROM mott powder/budesonide and thiamethoxam bromide treatment can without any increase in adverse drug reactions and improve therapeutic effect.