CAJ | 학술논문

长非编码 RNA（lncRNA）与肿瘤的发生发展、增殖迁移及临床预后密切相关，在许多肿瘤细胞发生耐药过程中起重要作用。体内外实验表明，lncRNA 可以通过多种信号通路、分子作用机制来调控肿瘤细胞发生耐药，并且阻断相关靶点后可以逆转这种耐药性。
장비편마 RNA（lncRNA）여종류적발생발전、증식천이급림상예후밀절상관，재허다종류세포발생내약과정중기중요작용。체내외실험표명，lncRNA 가이통과다충신호통로、분자작용궤제래조공종류세포발생내약，병차조단상관파점후가이역전저충내약성。
Long non-coding RNAs (lncRNAs)are closely related to the tumorigenesis,proliferation, metastasis and clinical outcome,whihc play important roles in the process of drug resistance of many tumor cells.Recently,research indicates that many lncRNAs regulate drug resistance of tumor cells through a variety of signaling pathways both in vitro and in vivo.Furthermore,it is also found that after blocking the relevant tar-gets can reverse this chemoresistance.