国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2015年
3期
328-330
,共3页
心肌损伤%E-选择素%白细胞介素-6%肿瘤坏死因子-α
心肌損傷%E-選擇素%白細胞介素-6%腫瘤壞死因子-α
심기손상%E-선택소%백세포개소-6%종류배사인자-α
Myocardial damage%E-selectin%Inter,leukin-6%Tumor necrosis factor-α
目的 评价心肌损伤患儿E-选择素、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)检测的临床价值.方法 检测62例心肌损伤患儿(心肌损伤组)和62例同期无心肌损伤的患儿(对照组)的E-选择素、IL-6和TNF-α表达水平,使用ROC曲线分析E-选择素、IL-6和TNF-α在心肌损伤中患儿的诊断价值.结果 心肌损伤组和对照组患儿E-选择素分别为(45.16±5.34)μg/L、(15.37 ±4.65) μg/L,两组间差异有统计学意义(P ＜0.001);IL-6分别为(21.31±5.28) ng/L、(17.09 ±4.62) ng/L,TNF-α分别为(27.22±8.56) ng/L、(21.46±8.08) ng/L,两组间差异均无统计学意义(P均＞0.05).ROC曲线分析显示E-选择素诊断心肌损伤的曲线下面积为0.945,95％ CI为0.899～0.991,敏感性、特异性、约登指数分别为0.801、0.999和0.800,诊断界值为29.93 μg/L.结论 E-选择素可作为心肌损伤的诊断参考指标之一,具有较高的诊断价值.IL-6及TNF-α对心肌损伤的诊断价值有限.
目的 評價心肌損傷患兒E-選擇素、白細胞介素-6(interleukin-6,IL-6)、腫瘤壞死因子-α(tumor necrosis factor-α,TNF-α)檢測的臨床價值.方法 檢測62例心肌損傷患兒(心肌損傷組)和62例同期無心肌損傷的患兒(對照組)的E-選擇素、IL-6和TNF-α錶達水平,使用ROC麯線分析E-選擇素、IL-6和TNF-α在心肌損傷中患兒的診斷價值.結果 心肌損傷組和對照組患兒E-選擇素分彆為(45.16±5.34)μg/L、(15.37 ±4.65) μg/L,兩組間差異有統計學意義(P ＜0.001);IL-6分彆為(21.31±5.28) ng/L、(17.09 ±4.62) ng/L,TNF-α分彆為(27.22±8.56) ng/L、(21.46±8.08) ng/L,兩組間差異均無統計學意義(P均＞0.05).ROC麯線分析顯示E-選擇素診斷心肌損傷的麯線下麵積為0.945,95％ CI為0.899～0.991,敏感性、特異性、約登指數分彆為0.801、0.999和0.800,診斷界值為29.93 μg/L.結論 E-選擇素可作為心肌損傷的診斷參攷指標之一,具有較高的診斷價值.IL-6及TNF-α對心肌損傷的診斷價值有限.
목적 평개심기손상환인E-선택소、백세포개소-6(interleukin-6,IL-6)、종류배사인자-α(tumor necrosis factor-α,TNF-α)검측적림상개치.방법 검측62례심기손상환인(심기손상조)화62례동기무심기손상적환인(대조조)적E-선택소、IL-6화TNF-α표체수평,사용ROC곡선분석E-선택소、IL-6화TNF-α재심기손상중환인적진단개치.결과 심기손상조화대조조환인E-선택소분별위(45.16±5.34)μg/L、(15.37 ±4.65) μg/L,량조간차이유통계학의의(P ＜0.001);IL-6분별위(21.31±5.28) ng/L、(17.09 ±4.62) ng/L,TNF-α분별위(27.22±8.56) ng/L、(21.46±8.08) ng/L,량조간차이균무통계학의의(P균＞0.05).ROC곡선분석현시E-선택소진단심기손상적곡선하면적위0.945,95％ CI위0.899～0.991,민감성、특이성、약등지수분별위0.801、0.999화0.800,진단계치위29.93 μg/L.결론 E-선택소가작위심기손상적진단삼고지표지일,구유교고적진단개치.IL-6급TNF-α대심기손상적진단개치유한.
Objective To investigate the value of the E-selectin,IL-6 and TNF-α for the diagnosis of myocardial damage in children.Methods The E-selectin,IL-6 and TNF-α levels were detected in 62 patients with myocardial damage and 62 children without myocardial damage.The values of the E-selectin,IL-6 and TNF-α for the diagnosis of myocardial damage were analyzed by the receiver operating characteristic (ROC) curve.Results E-selectin levels were (45.16 ± 5.34) and (15.37 ± 4.65) μg/L,respectively in the patients with myocardial damage and the control group,and the difference between the two groups was significant(P ＜ 0.001).IL-6 levels were (21.31 ± 5.28) ng/L and (17.09 ± 4.62) ng/L,TNF-α levels were (27.22 ± 8.56) ng/L and(21.46 ± 8.08) ng/L,showing no significant difference (P ＞ 0.05).ROC curve analysis showed that AOC of E-selectin in the diagnosis of myocardial damage was 0.945 with 95％ CI 0.899 ～0.991 (sensitivity:0.801,specificity:0.999,Youden Index:0.800),and the cutoff value was 29.93 μg/L.Conclusion E-selectin can be used as one of the diagnostic indices for myocardial damage in children,which has great diagnostic value.IL-6 and TNF-α are of limited value in the diagnosis of myocardial damage.
