云南中医学院学报
雲南中醫學院學報
운남중의학원학보
JOURNAL OF YUNNAN COLLEGE OF TRADITIONAL CHINESE MEDICINE
2015年
3期
43-46
,共4页
银芷肛肠熏洗剂%痔组织%细胞因子%血管内皮生长因子%CD68%基质金属蛋白酶9
銀芷肛腸熏洗劑%痔組織%細胞因子%血管內皮生長因子%CD68%基質金屬蛋白酶9
은지항장훈세제%치조직%세포인자%혈관내피생장인자%CD68%기질금속단백매9
YinZhi anorectal smoked lotion%hemorrhoidal tissue%cytokines factor%VEGF%CD68%MMP9
目的：观察银芷肛肠熏洗剂对痔组织VEGF、CD68、MMP9的影响。方法选取痔急性发作期患者40例，随机分为治疗组和对照组各20例。治疗组予银芷肛肠熏洗剂，对照组予金玄痔科熏洗散，肛门局部熏洗连续治疗后7d，取痔组织进行免疫组化染色检查，并与未用药直接手术痔患者（空白组）的组织进行对比，观察药物对痔组织VEGF、CD68、MMP9的影响。结果给药后银芷肛肠熏洗剂治疗组及金玄痔科熏洗散对照组抑制VEGF、CD68、MMP9表达的作用均优于空白组（P<0.01）；银芷肛肠熏洗剂抑制VEGF、CD68、MMP9的作用优于金玄痔科熏洗散对照组（P<0.01/0.05）。结论银芷肛肠熏洗剂能抑制痔组织VEGF、CD68、MMP9的表达，其对痔的治疗作用可能与抑制VEGF、CD68、MMP9表达有关。
目的：觀察銀芷肛腸熏洗劑對痔組織VEGF、CD68、MMP9的影響。方法選取痔急性髮作期患者40例，隨機分為治療組和對照組各20例。治療組予銀芷肛腸熏洗劑，對照組予金玄痔科熏洗散，肛門跼部熏洗連續治療後7d，取痔組織進行免疫組化染色檢查，併與未用藥直接手術痔患者（空白組）的組織進行對比，觀察藥物對痔組織VEGF、CD68、MMP9的影響。結果給藥後銀芷肛腸熏洗劑治療組及金玄痔科熏洗散對照組抑製VEGF、CD68、MMP9錶達的作用均優于空白組（P<0.01）；銀芷肛腸熏洗劑抑製VEGF、CD68、MMP9的作用優于金玄痔科熏洗散對照組（P<0.01/0.05）。結論銀芷肛腸熏洗劑能抑製痔組織VEGF、CD68、MMP9的錶達，其對痔的治療作用可能與抑製VEGF、CD68、MMP9錶達有關。
목적：관찰은지항장훈세제대치조직VEGF、CD68、MMP9적영향。방법선취치급성발작기환자40례，수궤분위치료조화대조조각20례。치료조여은지항장훈세제，대조조여금현치과훈세산，항문국부훈세련속치료후7d，취치조직진행면역조화염색검사，병여미용약직접수술치환자（공백조）적조직진행대비，관찰약물대치조직VEGF、CD68、MMP9적영향。결과급약후은지항장훈세제치료조급금현치과훈세산대조조억제VEGF、CD68、MMP9표체적작용균우우공백조（P<0.01）；은지항장훈세제억제VEGF、CD68、MMP9적작용우우금현치과훈세산대조조（P<0.01/0.05）。결론은지항장훈세제능억제치조직VEGF、CD68、MMP9적표체，기대치적치료작용가능여억제VEGF、CD68、MMP9표체유관。
Objective To observe effect of YinZhi anorectal smoked lotion acting on the hemorrhoid tissue cytokines factor VEGF、CD68 and MMP9. Methods Selected 40 cases of acute episode of hemorrhoid patients were randomly divided into 20 patients in each treatment group and the control group. The treatment group were cured with YinZhi anorectal smoked lotion and the control group were cured with Ma Ying-Long Jin Xuan hemorrhoid washing powder,All two group were fumigated partialy on anal after 7 consecutive days. The hemorrhoid tissue gotten from patients compare with that were cured through surgery directly without medication by immunohistochemical staining examination. Observe the effect of medication on hemorrhoid tissue cytokines factor VEGF、CD68 and MMP9. Results After medical treatment,YinZhi anorectal smoked lotion treatment group and Ma Ying-Long Jin Xuan hemorrhoid washing powder control group is better than blank group about inhibiting VEGF,CD68,MMP9 expression(P<0.01);YinZhi anorectal smoked lotion treatment group is better than Ma Ying-Long Jin Xuan hemorrhoid washing powder control group(P<0.01/0.05). Conclusion YinZhi anorectal smoked lotion inhibits expression of hemorrhoidal tissue cytokines factor VEGF、CD68 and MMP9. The therapeutical effect of YinZhi anorectal smoked lotion acting on hemorrhoidal tissue is possibly related with expression of inhibiting VEGF,CD68,MMP9.
