CAJ | 학술논문

目的：研究人体内维生素A( vitamin A,VA)水平与肺表面活性蛋白( surfactant pro-teins,SP)-B、SP-C的相关性,以及对新生儿肺发育和肺功能的影响。方法收集170例孕妇血清及所产新生儿的脐带血清,用ELISA试剂盒检测母亲和新生儿血清中VA水平及新生儿脐带血清中SP-B、SP-C的含量。在新生儿出生6个月后,通过标准的电话问卷调查进行一次随访,内容为生后半年内有无呼吸道感染及感染的次数,以此来评估新生儿生后半年内肺功能的情况。结果(1)新生儿脐带血中VA含量与母亲血清中VA含量呈正相关(r=0．866,P<0．05)；(2)新生儿脐带血中VA含量与SP-B、SP-C含量呈正相关(r=0．817,P<0．05),且不受其母亲产前VA水平影响；(3)随访发现,170例婴儿中有3例在半年内因肺炎住院1次及以上,但无呼吸窘迫综合征发生。结论 VA可以作为新生儿肺成熟的重要生物标记物,通过检测产前孕妇的VA水平,适当补充VA,可以提高新生儿SP-B、SP-C的含量,提高新生儿在以后生长发育中的肺功能。
목적：연구인체내유생소A( vitamin A,VA)수평여폐표면활성단백( surfactant pro-teins,SP)-B、SP-C적상관성,이급대신생인폐발육화폐공능적영향。방법수집170례잉부혈청급소산신생인적제대혈청,용ELISA시제합검측모친화신생인혈청중VA수평급신생인제대혈청중SP-B、SP-C적함량。재신생인출생6개월후,통과표준적전화문권조사진행일차수방,내용위생후반년내유무호흡도감염급감염적차수,이차래평고신생인생후반년내폐공능적정황。결과(1)신생인제대혈중VA함량여모친혈청중VA함량정정상관(r=0．866,P<0．05)；(2)신생인제대혈중VA함량여SP-B、SP-C함량정정상관(r=0．817,P<0．05),차불수기모친산전VA수평영향；(3)수방발현,170례영인중유3례재반년내인폐염주원1차급이상,단무호흡군박종합정발생。결론 VA가이작위신생인폐성숙적중요생물표기물,통과검측산전잉부적VA수평,괄당보충VA,가이제고신생인SP-B、SP-C적함량,제고신생인재이후생장발육중적폐공능。
Objective To investigate the correlation between vitamin A and surfactant protein (SP)-B, SP-C in human body,and to explore the effects on lung development and pulmonary function of neonates. Methods We collected the blood samples of 170 pregnant women and umbilical cord serum of their neonatal babies. The levels of vitamin A in pregnant women and their neonatal babies,and the levels of SP-B and SP-C in neonatal umbilical cord serum were detected by ELISA. We conducted a follow-up by standard telephone questionnaire,which we concerned was the number of respiratory tract infection within six months,in order to assess the neonatal pulmonary functions. Results (1) There was a positive correlation between the vitamin A levels in neonatal umbilical cord blood and in the blood of pregnant women(r=0. 866,P<0. 05). (2) There was a positive correlation between the vitamin A levels in neonatal umbilical cord blood and the levels of SP-B,SP-C in the blood(r=0. 817,P<0. 05). (3)In the follow-up of 170 cases of infants within six months,three cases with pneumonia hospitalized more than once,but no respiratory distress syndrome hap-pened. Conclusion Vitamin A can be used as an important biological marker to evaluate the neonatal pul-monary maturity. If we detect the vitamin A levels of pregnant women,increase the intake of vitamin A,we can improve the content of SP-B,SP-C,improve the development of neonatal lung function in growth.