CAJ | 학술논문

目的：比较不同浓度聚桂醇在留置10 m in后抽出和留置不抽出两种方式下对大鼠子宫内膜异位囊肿模型硬化效果的差异。方法90只SD大鼠造模后随机分为3组：A组，留置10 min后抽出；B组，留置不抽出；C组，生理盐水对照。其中A、B各组再随机分为四个不同浓度亚组：1％、05．％、02．5％、01．25％。治疗7 d后统计治愈率并观察组织病理学改变。结果 A 组治愈率分别为867．％、714．％、50％、20％，B组治愈率分别为100％、100％、875．％、375．％。A、B两组内1％、05．％及02．5％浓度亚组之间治愈率差异均无统计学意义（P ＞00．5），B组中上述3个浓度亚组与01．25％浓度亚组及生理盐水对照组治愈率差异有统计学意义（P ＜00．5），但A组中02．5％与01．25％浓度亚组治愈率差异无统计学意义。A、B两组间各相同浓度组比较，1％、01．25％浓度亚组两种留置方式治愈率差异无统计学意义（ P ＞00．5），而05．％、02．5％浓度亚组两种留置方式治愈率差异有统计学意义（P ＜00．5）。结论聚桂醇作用浓度保持在02．5％以上时，注入囊肿模型后不抽出有助于增强硬化效果。
목적：비교불동농도취계순재류치10 m in후추출화류치불추출량충방식하대대서자궁내막이위낭종모형경화효과적차이。방법90지SD대서조모후수궤분위3조：A조，류치10 min후추출；B조，류치불추출；C조，생리염수대조。기중A、B각조재수궤분위사개불동농도아조：1％、05．％、02．5％、01．25％。치료7 d후통계치유솔병관찰조직병이학개변。결과 A 조치유솔분별위867．％、714．％、50％、20％，B조치유솔분별위100％、100％、875．％、375．％。A、B량조내1％、05．％급02．5％농도아조지간치유솔차이균무통계학의의（P ＞00．5），B조중상술3개농도아조여01．25％농도아조급생리염수대조조치유솔차이유통계학의의（P ＜00．5），단A조중02．5％여01．25％농도아조치유솔차이무통계학의의。A、B량조간각상동농도조비교，1％、01．25％농도아조량충류치방식치유솔차이무통계학의의（ P ＞00．5），이05．％、02．5％농도아조량충류치방식치유솔차이유통계학의의（P ＜00．5）。결론취계순작용농도보지재02．5％이상시，주입낭종모형후불추출유조우증강경화효과。
Objective To compare the sclerotherapic effects of different concentrations of lauromacrogol on endometrial cyst models in rats in two ways :10 minutes retention with extraction and retention without extraction .Methods Ninety SD rats after modeling were randomly divided into three groups :group A ,10 minutes retention with extraction;group B ,retention without extraction;group C , normal saline .While both A and B group were randomly divided into four subgroups with different concentrations :1% ,0 5.% ,0 2.5% ,and 0 1.25% . Seven days after treatment the cure rates and histopathological changes were observed .Results Cure rates in group A were 86 7.% ,71 4.% ,50% and 20% ;in group B were 100% ,100% ,87 5.% and 37 5.% .In both A and B groups ,the cure rates were not significantly different between 1% ,0 5.% and 0 2.5% concentration subgroups ( P >0 0.5) ,the cure rates of these subgroups in group B had statistical significance with 0 1.25% concentration subgroups and the saline control group( P <0 0.5) ,but there were no significant difference between 0 2.5% and 0 1.25% concentration subgroups in group A .Compared the differences of the cure rates among the same concentration subgroups , it had no statistical significance in groups A and B of 1% and 0 1.25% concentration subgroups( P >0 0.5) , but between 0 5.% and 0 2.5% concentration subgroups ,it had statistical significance( P <0 0.5) .Conclusions It will be conductive to enhancing the sclerotherapic effect if the lauromacrogol concentration remains above 0 2.5% and does not be extracted from the cyst models .