CAJ | 학술논문

目的：评估酒精依赖综合征患者的认知功能状态，为酒精依赖者临床诊疗与评估提供研究基础，为这类患者有无完全或部分责任能力的评判提供参考依据。方法选取27名酒精依赖综合征患者，分别于治疗前后进行视觉选择反应时和划消效率两项测试，同时选取30名性别、年龄、文化程度与酒精依赖综合征患者相匹配的健康志愿者，分别于饮酒前后进行相同测试，所得数据进行方差分析。结果相对于健康人群，酒精依赖患者的视觉反应时和划消效率均存在显著差异(P＜0.01)，并且治疗前后相比差异也具有统计学意义(P＜0.05)，而健康人饮酒前后无统计学意义(P＞0.05)。结论酒精依赖患者部分认知功能受到了不可逆的损害。
목적：평고주정의뢰종합정환자적인지공능상태，위주정의뢰자림상진료여평고제공연구기출，위저류환자유무완전혹부분책임능력적평판제공삼고의거。방법선취27명주정의뢰종합정환자，분별우치료전후진행시각선택반응시화화소효솔량항측시，동시선취30명성별、년령、문화정도여주정의뢰종합정환자상필배적건강지원자，분별우음주전후진행상동측시，소득수거진행방차분석。결과상대우건강인군，주정의뢰환자적시각반응시화화소효솔균존재현저차이(P＜0.01)，병차치료전후상비차이야구유통계학의의(P＜0.05)，이건강인음주전후무통계학의의(P＞0.05)。결론주정의뢰환자부분인지공능수도료불가역적손해。
ABSTRACT:ObjectiveTo assess cognitive function in patients with alcohol dependence syndrome to provide a foundation of clinical diagnosis and treatment for such kind of disease and offer a reference for evaluating whether alcohol-dependent patients are able to take responsibility, either full or partial.Methods27 patients with alcohol dependence syndrome were chosen and received two tests of visual choice reaction time and cancellation efficiency before and after treatment, respectively. 30 healthy volunteers, whose gender, age and education background were matched with the patients, were selected as the control group and received the above same two tests before and after drinking alcohol but with the latter being conducted when no signs of ethanol and acetaldehyde showing in the subject’s blood. Finally the data were processed with the analysis of variance.ResultsCompared with the control group, the patients of alcohol dependence syndrome had statistically significant difference in the two tests either pre- or post- treatment (P<0.01). There were also significant changes for the patients of alcohol dependence syndrome between pre- and post- treatment (P<0.05) whereas none for the healthy volunteers before and after drinking (P>0.05).ConclusionsPart of the cognitive function of alcohol-dependent patients is damaged irreversibly no matter whether treatment has been made or not.