CAJ | 학술논문

目的：通过检测先兆流产患者用黄体酮治疗前后血清中孕酮（ P）和孕激素诱导的阻断因子（ PIBF）的表达水平，探讨 PIBF的临床意义及与P的相关关系。方法选取70例正常早孕妇为对照组，辅以常规安胎处置，70例早期先兆流产者为实验组，除常规处置外加用黄体酮治疗，检测处置前后两组血清中P及PIBF的浓度，分析相关性。结果治疗前实验组的血清PIBF水平明显低于对照组（ P＜0.05），而治疗后实验组的血清PIBF水平逐渐提升至与对照组相近（P＞0.05）；治疗前实验组的P浓度远低于对照组（P＜0.05），治疗后实验组血清P浓度提升到甚至超过对照组水平；对照组血清P及PIBF呈正相关（r＝0.376，P＜0.01），但实验组中血清P及 PIBF 浓度又不具备显著相关关系（r＝0.212，P ＞0.05）；结论血清PIBF水平的检测能为早期先兆流产使用黄体酮治疗提供实验室依据，帮助预测妊娠的结局，值得推广。
목적：통과검측선조유산환자용황체동치료전후혈청중잉동（ P）화잉격소유도적조단인자（ PIBF）적표체수평，탐토 PIBF적림상의의급여P적상관관계。방법선취70례정상조잉부위대조조，보이상규안태처치，70례조기선조유산자위실험조，제상규처치외가용황체동치료，검측처치전후량조혈청중P급PIBF적농도，분석상관성。결과치료전실험조적혈청PIBF수평명현저우대조조（ P＜0.05），이치료후실험조적혈청PIBF수평축점제승지여대조조상근（P＞0.05）；치료전실험조적P농도원저우대조조（P＜0.05），치료후실험조혈청P농도제승도심지초과대조조수평；대조조혈청P급PIBF정정상관（r＝0.376，P＜0.01），단실험조중혈청P급 PIBF 농도우불구비현저상관관계（r＝0.212，P ＞0.05）；결론혈청PIBF수평적검측능위조기선조유산사용황체동치료제공실험실의거，방조예측임신적결국，치득추엄。
OBJECTIVE To investigate the expression and clinical significance of progesterone( P) and proges-terone-induced blocking factor( PIBF) in serum of patients with spontaneous abortion before and after the progester-one therapy.METHODS The 70 cases of healthy pregnant women were chosen as control group and received Con-ventional treatment,while the other 70 patients with spontaneous abortion were selected as experimental group,treated as the control group but joint progesterone.The PIBF and P concentrations in serum of 2 groups were measured and the results were analysed;RESULTS PIBF and P in serum of experimental group were lower than those in control group before the treatment ( P<0.05 ).PIBF was close to and P was even higher than the control group after the treatment.In contrast with control group.no linear correlation was found between the serum P and PIBF expressions in the exprimental groups(P>0.05).CONCLUSION Detection of serum PIBF for early threatened abortion can provide laboratory evidence for progesterone treatment,predicting the outcome of pregnancy,and worth promotion.