CAJ | 학술논문

了解吸烟情况与不同类型乳腺癌发病的关系。采用病例对照研究方法，对于我院就诊并经病理证实的250例女性乳腺癌患者和同期就诊的360例同年龄组非乳腺癌患者进行相关危险因素问卷调查，并将结果进行统计学分析。吸烟女性患乳腺癌风险为未吸烟女性的3．7倍（95％ CI：2．570～5．408），以病理类型分层分析，吸烟患者雌激素受体（ER）阳性乳腺癌患病风险增加4．4倍（95％ CI：2．991～6．494），患三阴性乳腺癌（TNBC）风险无明显增加（OR＝1．4，95％ CI：0．695～3．174）。因此吸烟行为可增加女性ER阳性乳腺癌患病风险，而与T NBC尚无确切关系。
료해흡연정황여불동류형유선암발병적관계。채용병례대조연구방법，대우아원취진병경병리증실적250례녀성유선암환자화동기취진적360례동년령조비유선암환자진행상관위험인소문권조사，병장결과진행통계학분석。흡연녀성환유선암풍험위미흡연녀성적3．7배（95％ CI：2．570～5．408），이병리류형분층분석，흡연환자자격소수체（ER）양성유선암환병풍험증가4．4배（95％ CI：2．991～6．494），환삼음성유선암（TNBC）풍험무명현증가（OR＝1．4，95％ CI：0．695～3．174）。인차흡연행위가증가녀성ER양성유선암환병풍험，이여T NBC상무학절관계。
The aim was to analyze whether smoking is associated differentially with risks of the major breast cancer sub‐types .This was a case‐control study of 250 women with breast cancer who were diagnosed in our hospital .A control group of 360 cancer‐free women also was included .The data was analyzed by statistics software .Ever‐smokers had a 3 .7‐fold increased risk (95% CI:2 .570~5 .408) of breast cancer overall;and ,when stratified by cancer subtype ,they had a 4 .4‐fold increased risk (95% CI:2 .991~6 .494) of ER‐positive breast cancer ,but there was no elevation in their risk of triple negative disease (TNBC) (OR=1 .4 ,95% CI:0 .695~3 .174) .The current results suggested that women who are smokers with high pack‐year histories may have an increased risk of ER‐positive breast cancer but not TNBC .