中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2015年
5期
452-456
,共5页
食品安全%危险性评估%决策树%毒理学关注阈值
食品安全%危險性評估%決策樹%毒理學關註閾值
식품안전%위험성평고%결책수%독이학관주역치
Food safety%Risk assessment%Decision trees%Threshold of toxicological concern
毒理学关注阈值是一种科学实用的食品中化学物风险评估方法，也是风险管理中对各种化学物风险评估的优先性进行识别和筛选的有效工具。但由于这一方法是在缺少常规的毒性资料的前提下，试图通过化学物的结构对化学物进行风险特征描述，所以在其应用方面目前仍然存在不少争议。本文结合毒理关注阈值方法的原理、要素及在应用方面的最新进展，就其在化学物风险评估中需要考虑的关键问题进行探讨和总结。
毒理學關註閾值是一種科學實用的食品中化學物風險評估方法，也是風險管理中對各種化學物風險評估的優先性進行識彆和篩選的有效工具。但由于這一方法是在缺少常規的毒性資料的前提下，試圖通過化學物的結構對化學物進行風險特徵描述，所以在其應用方麵目前仍然存在不少爭議。本文結閤毒理關註閾值方法的原理、要素及在應用方麵的最新進展，就其在化學物風險評估中需要攷慮的關鍵問題進行探討和總結。
독이학관주역치시일충과학실용적식품중화학물풍험평고방법，야시풍험관리중대각충화학물풍험평고적우선성진행식별화사선적유효공구。단유우저일방법시재결소상규적독성자료적전제하，시도통과화학물적결구대화학물진행풍험특정묘술，소이재기응용방면목전잉연존재불소쟁의。본문결합독리관주역치방법적원리、요소급재응용방면적최신진전，취기재화학물풍험평고중수요고필적관건문제진행탐토화총결。
Threshold of toxicological concern(TTC)is a scientific and practical method for the food safety risk assessment of chemicals, and also an useful tool for the identification and screening of chemicals with risk assessment priority. However, there were still controversial opinions concerning the application of this method, which was established to provide risk characterization on the bases of chemical structures whereas in the lack of conventional toxicological data. Here, we reviewed the principles, critical factors, and recent progress in the application of TTC method, to explore and summarize the critical aspects that need particular considerations in the risk assessment of chemicals.
