海峡药学
海峽藥學
해협약학
STRAIT PHARMACEUTICAL JOURNAL
2015年
5期
38-40
,共3页
王梅兰%黄亦琦%曹育%杨辉%黄颖%凡希承%林向党
王梅蘭%黃亦琦%曹育%楊輝%黃穎%凡希承%林嚮黨
왕매란%황역기%조육%양휘%황영%범희승%림향당
全蚕粉%链脲佐菌素%2型糖尿病%大鼠%动物模型
全蠶粉%鏈脲佐菌素%2型糖尿病%大鼠%動物模型
전잠분%련뇨좌균소%2형당뇨병%대서%동물모형
Silkworm powder( SP)%Streptozotocin( STZ)%Type 2 diabetes%Animal model%Rats
目的：研究全蚕粉对2型糖尿病大鼠的治疗作用。方法用高热量饲料喂养4周后腹腔注射 STZ 25mg· kg －1制造2型糖尿病模型大鼠，以不同剂量全蚕粉灌胃治疗6周，观察血糖、血脂、血清胰岛素、超氧化物歧化酶SOD、丙二醛MDA指标的变化。结果全蚕粉能改善2型糖尿病模型大鼠的糖、脂代谢，促进清除自由基，保护细胞的作用。结论全蚕粉能有效治疗2型糖尿病大鼠。
目的：研究全蠶粉對2型糖尿病大鼠的治療作用。方法用高熱量飼料餵養4週後腹腔註射 STZ 25mg· kg －1製造2型糖尿病模型大鼠，以不同劑量全蠶粉灌胃治療6週，觀察血糖、血脂、血清胰島素、超氧化物歧化酶SOD、丙二醛MDA指標的變化。結果全蠶粉能改善2型糖尿病模型大鼠的糖、脂代謝，促進清除自由基，保護細胞的作用。結論全蠶粉能有效治療2型糖尿病大鼠。
목적：연구전잠분대2형당뇨병대서적치료작용。방법용고열량사료위양4주후복강주사 STZ 25mg· kg －1제조2형당뇨병모형대서，이불동제량전잠분관위치료6주，관찰혈당、혈지、혈청이도소、초양화물기화매SOD、병이철MDA지표적변화。결과전잠분능개선2형당뇨병모형대서적당、지대사，촉진청제자유기，보호세포적작용。결론전잠분능유효치료2형당뇨병대서。
OBJECTIVE To study the effects of silkworm powder(SP) on the rats suffered with type 2 diabe-tes.METHODS The rats suffered with type 2 diabetes were induced by injecting STZ 25mg· kg -1 peritonaeumly after fed with high carlorie food for 4 weeks and divided into six groups randomizely,treated them with different drugs and variety dosages for 6 weeks.Then the glucose,lipide,insulin,SOD,MDA in blood plasm of the rats were detec-ted.RESULTS SP could reduced glucose,lipide,MDA concentration,increased insulin and enhanced the enzyme activity of SOD in the rats′blood plasm significantely.CONCLUSION SP is effective in treating rats suffered with type 2 diabetes.
