CAJ | 학술논문

目的：评价有证参考物质、室间质量评价计划材料、校准品等血清葡萄糖参考物质在24种常规分析系统上的互通性。方法方法学评价。用血清葡萄糖同位素稀释液相色谱串联质谱法为比对方法，血糖常规方法的24种测定系统为待评方法，测定35份单人份冰冻血清和多种参考物质，评价这些物质在各个系统上的互通性。结果5种有证参考物质、2种正确度验证计划材料、5种校准品在参加评价的24种系统上具有良好的互通性。其他参考物质显示不同程度的互通性问题。结论应充分重视互通性问题对血清葡萄糖测定量值传递的影响。（中华检验医学杂志，2015，38：296－300）
목적：평개유증삼고물질、실간질량평개계화재료、교준품등혈청포도당삼고물질재24충상규분석계통상적호통성。방법방법학평개。용혈청포도당동위소희석액상색보천련질보법위비대방법，혈당상규방법적24충측정계통위대평방법，측정35빈단인빈빙동혈청화다충삼고물질，평개저사물질재각개계통상적호통성。결과5충유증삼고물질、2충정학도험증계화재료、5충교준품재삼가평개적24충계통상구유량호적호통성。기타삼고물질현시불동정도적호통성문제。결론응충분중시호통성문제대혈청포도당측정량치전체적영향。（중화검험의학잡지，2015，38：296－300）
Objective To evaluate the commutability of certified reference materials, external quality assessment program materials and calibrators for serum glucose measurements which were performed in 24 routine measurement procedures.Methods 35 fresh patient specimens and some reference materials were analyzed by isotope dilution liquid chromatography tandem mass spectrometry ( as the comparative method) and 24 routine measurement procedures (as the evaluated methods).The relationships between the results from the evaluated method and the comparative methods were evaluated to identify the commutability.Results It showed that 5 certified reference materials, 2 trueness verification materials, and 5 calibrators were commutable in all 24 routine measurement procedures.The other samples were displayed the presence of commutability issue in different degrees.Conclusion It is important to pay more attention to the problems brought by commutability of reference materials in clinical laboratory.