CAJ | 학술논문

目的：研究小儿碳酸钙维D3咀嚼片的处方工艺及检查方法。方法处方采用正交试验，通过对辅料用量的筛选为考察项目，以颗粒休止角为考察指标，最终确定最优的处方及工艺。结果采用辅料麦芽糊精、阿司巴坦、枸橼酸、山梨醇做为辅料，采用20目筛网制粒，在60℃条件下烘干，水分控制在2.5％以下，稳定性良好，符合质量要求。结论采用该处方及生产工艺，符合咀嚼片剂的要求，可以用于大生产。
목적：연구소인탄산개유D3저작편적처방공예급검사방법。방법처방채용정교시험，통과대보료용량적사선위고찰항목，이과립휴지각위고찰지표，최종학정최우적처방급공예。결과채용보료맥아호정、아사파탄、구연산、산리순주위보료，채용20목사망제립，재60℃조건하홍간，수분공제재2.5％이하，은정성량호，부합질량요구。결론채용해처방급생산공예，부합저작편제적요구，가이용우대생산。
OBJECTIVE The prescription process and inspection method on children Calcium Carbonate and Vitamin D3 Chewable Tablets.METHODS The prescription by orthogonal test,through the screening of excipients as research project,to the repose angle,tablet hardness,friability,content as the indexes,finally determined the opti-mal prescription and technology.RESULTS To usr the excipients maltodextrin,aspartame,citric acid,sorbitol as materials,using 20 mesh sieve granulation,drying in the 60 conditions,Moisture control below 2.5%,good stability and meet the quality requirements.CONCLUSION To use the materials and production process, in accordance with the requirements of a chewable tablet,Can be used for mass production.