CAJ | 학술논문

目的：通过检测围绝经期复发性子宫内膜异位症患者的FSH （卵泡生成激素）水平观察米非司酮的治疗效果。方法将2008年12月至2013年12月于我院接受治疗的62例围绝经期子宫内膜异位症患者作为研究对象，所有患者均给予米非司酮治疗，连续治疗6个月，比较治疗前后患者血FSH的水平变化以及停药3个月、6个月后血清FSH的水平。结果服药3个月后，患者血清FSH水平显著降低，降低至（9．12±2．09）μ／L，与服药前对比差异明显（P＜0．05）；服药6个月后，患者包块直径减少至（2．24±1．18）cm，明显低于治疗前（P＜0．05），血清FSH水平下降至（8．60±3．02）μ／L，与治疗前对比差异明显（P＜0．05）；停药3个月后，患者血清FSH水平为（21．32±1．51）μ／L，其中28例血FSH＞25U／L，剩余34例与治疗前无明显变化；停药6个月后患者血清FSH水平为（14．53±0．72）μ／L，明显低于停药3个月前，组间对比差异具备统计学意义（P＜0．05）；62例患者在接受6个月治疗后，28例过度到自然绝经，34例恢复月经来潮；随访1年复发10例，占16．13％，fsh水平为（25．21±1．62）μ／L，2年复发13例，占20．97％， fsh水平为（27．92±1．14）μ／L，复发者均继续接受米非司酮治疗。结论围绝经期复发性内异症患者在治疗过程中监测FSH水平可反映体内激素水平，准确评估治疗效果和预后，并可作为围绝经期复发性内异症患者治疗和预后的评价指标，为患者的复发治疗提供有效指导。
목적：통과검측위절경기복발성자궁내막이위증환자적FSH （란포생성격소）수평관찰미비사동적치료효과。방법장2008년12월지2013년12월우아원접수치료적62례위절경기자궁내막이위증환자작위연구대상，소유환자균급여미비사동치료，련속치료6개월，비교치료전후환자혈FSH적수평변화이급정약3개월、6개월후혈청FSH적수평。결과복약3개월후，환자혈청FSH수평현저강저，강저지（9．12±2．09）μ／L，여복약전대비차이명현（P＜0．05）；복약6개월후，환자포괴직경감소지（2．24±1．18）cm，명현저우치료전（P＜0．05），혈청FSH수평하강지（8．60±3．02）μ／L，여치료전대비차이명현（P＜0．05）；정약3개월후，환자혈청FSH수평위（21．32±1．51）μ／L，기중28례혈FSH＞25U／L，잉여34례여치료전무명현변화；정약6개월후환자혈청FSH수평위（14．53±0．72）μ／L，명현저우정약3개월전，조간대비차이구비통계학의의（P＜0．05）；62례환자재접수6개월치료후，28례과도도자연절경，34례회복월경래조；수방1년복발10례，점16．13％，fsh수평위（25．21±1．62）μ／L，2년복발13례，점20．97％， fsh수평위（27．92±1．14）μ／L，복발자균계속접수미비사동치료。결론위절경기복발성내이증환자재치료과정중감측FSH수평가반영체내격소수평，준학평고치료효과화예후，병가작위위절경기복발성내이증환자치료화예후적평개지표，위환자적복발치료제공유효지도。
Objective To investigate the efficacy of mifepristone in treating recurrent endometriosis by detecting the level of FSH ( follicle stimulating hormone ) .Methods Selected 62 cases of perimenopausal recurrent endometriosis patients treated in our hospital during December 2008 and December 2011 as research object, all the patients were given mifepristone for treatment , and the patients were continuously treated for 6 months.The changes of FSH levels before and after treatment and the level of FSH 3 and 6 months after the drug withdrawal.Results After taking the medicine for 3 months, the level of serum FSH reduced to (9.12 ±2.09) u/l, compared with the level before taking the medicine , the difference was statistically significant (P <0.05). 6 months after the treatment, lump diameter reduced to (2.24 ±1.18) cm, which significantly lower than that before treatment (P<0.05), and the serum level of FSH decreased to (8.60 ±3.02) u/l, compared with those before the treatment, differences were statistically significant (P<0.05).After drug withdrawal for 3 months, the level of serum FSH was (21.32 ±1.51) u/l, including 28 cases of blood FSH >25U/L, the remaining 34 cases had no obvious change .The level of serum FSH was (14.53 ±0.72) u/l 6 months after stop taking drugs , it was significantly lower than that of drug withdrawal 3 months ago , the difference was statistically significant ( P<0.05).During the 6 months'period of treatment, 28 cases developed to natural menopause , 34 cases recovered menstruation.Followed-up for one year, recurrence occurred in 10 cases, accounting for 16.13%, FSH level was 25.21 ±1.62 u/l.When followed-up for 2 years recurrence occurred in 13 cases, accounted for 20.97%, FSH level was 27.92 ±1.14 u/l.All recurrence patients received mifepristone treatment continuously . Conclusions FSH monitoring can reflect hormone level of patients , assess efficacy and prognosis exactly .It can be used as an index which assessing the efficacy and prognosis of recurrent endometriosis and provide effective guidance for recurrent patients .