CAJ | 학술논문

目的探讨血清CTRP鄄9水平和内脏脂肪分布部位对代谢综合征( MS)的影响。方法选取88例代谢综合征患者,分为MS组42例,对照组46例。通过64排双源心脏CT测量心外膜脂肪体积( EATV )。ELISA法检测血清CTRP鄄9、脂联素( APN)及瘦素水平。结果MS组患者的腰围、BMI、EATV、TG、空腹血糖、HOMA鄄IR明显高于对照组,而HDL鄄C、APN和CTRP鄄9水平显著低于对照组(P<0.05)；EATV、腰围和BMI对MS均有诊断预测价值；调整血清APN水平后,血清CTRP鄄9与空腹血糖、EATV仍显著负相关( r=-0.390, P<0.001；r=-0.273,P=0.033),与HDL鄄C显著正相关(r=0.208,P=0.041)；EATV是影响MS的独立危险因素,而HDL鄄C、脂联素和CTRP鄄9是MS的保护因素。结论血清CTRP鄄9与EATV和代谢参数存在良好的相关性,此相关性独立于血清APN水平。 EATV是影响MS的独立危险因素,而CTRP鄄9是保护因素。
목적탐토혈청CTRP견9수평화내장지방분포부위대대사종합정( MS)적영향。방법선취88례대사종합정환자,분위MS조42례,대조조46례。통과64배쌍원심장CT측량심외막지방체적( EATV )。ELISA법검측혈청CTRP견9、지련소( APN)급수소수평。결과MS조환자적요위、BMI、EATV、TG、공복혈당、HOMA견IR명현고우대조조,이HDL견C、APN화CTRP견9수평현저저우대조조(P<0.05)；EATV、요위화BMI대MS균유진단예측개치；조정혈청APN수평후,혈청CTRP견9여공복혈당、EATV잉현저부상관( r=-0.390, P<0.001；r=-0.273,P=0.033),여HDL견C현저정상관(r=0.208,P=0.041)；EATV시영향MS적독립위험인소,이HDL견C、지련소화CTRP견9시MS적보호인소。결론혈청CTRP견9여EATV화대사삼수존재량호적상관성,차상관성독립우혈청APN수평。 EATV시영향MS적독립위험인소,이CTRP견9시보호인소。
Objective To investigate the effects of serum CTRP-9 levels and visceral fat distribution on the metabolic syndrome(MS). Method A total of 88 patients were collected from February 2013 to October 2013. Patients were divided into the metabolic syndrome group(42 cases) and control group(46 cases). Epicardial adipose tissue vol-umes ( EATV) were measured by dual-source 64-slice CT. Fasting blood sample were collected for biochemical ex-amination and cytokines by ELISA. Result The waist circum-ference, body mass index, EATV, TG, fasting glu-cose and HOMA-IR in patients with MS were significantly higher than those in patients with non-metabolic syn-drome, HDL-C, adiponectin and CTRP -9 in patients with MS were significantly lower than those in patients with non-metabolic syndrome(P<0. 05);The area under receiver operating characteristic (ROC) curve of EATV, waist circumference and BMI in diagnosis of MS were 0. 668(P=0. 007),0. 797(P<0. 001)and 0. 652(P=0. 014);Af-ter adjust the serum adiponectin level, serum CTRP-9 and fasting glucose, EATV were significantly negative corre-lation(r=-0. 390, P<0. 001 and r=-0. 273, P=0. 033), and HDL-C was significantly positive correlation (r= 0. 208, P=0. 041);EATV was an independent risk factor for MS,HDL-C, adiponectin and CTRP-9 were pro-tective factors for MS. Conclusion There were good correlations between serum CTRP-9 and EATV,and other meta-bolic parameters,the correlations were independent of the serum adiponectin levels. EATV was an independent risk factor and CTRP-9 was a protective factor for MS.