CAJ | 학술논문

目的：评估抗血管内皮生长因子(VEGF)药物在新生血管性青光眼治疗中的作用。方法选取新生血管性青光眼（NVG）患者58人63只眼，男性40人，女性18人，平均年龄（65.81±14.68）岁。根据患者是否接受抗VEGF治疗分为抗VEGF组和对照组。2组患者除抗VEGF治疗外，还进行其他治疗如滤过术、青光眼阀植入术、睫状体冷凝或光凝及视网膜光凝，且构成差异无统计学意义（P>0.05）。对2组患者治疗前后的眼压和视力进行统计学分析。结果抗VEGF组与对照组治疗后眼压均有明显下降。抗VEGF组自（49.35±12.57） mm Hg（1 mm Hg=0.133 kPa）下降至（14.6±7.29） mm Hg；对照组自（52.34±10.67） mm Hg下降至（17.1±6.93） mm Hg。2组治疗后1周至治疗后3个月各时点眼压之间比较，差异均无统计学意义（P>0.05）。抗VEGF组与对照组治疗后视力差异无统计学意义（P>0.05）。结论抗VEGF能够抑制虹膜及视网膜上新生血管的生成和发展，但在新生血管性青光眼的治疗中，尚无法明显地改善预后。
목적：평고항혈관내피생장인자(VEGF)약물재신생혈관성청광안치료중적작용。방법선취신생혈관성청광안（NVG）환자58인63지안，남성40인，녀성18인，평균년령（65.81±14.68）세。근거환자시부접수항VEGF치료분위항VEGF조화대조조。2조환자제항VEGF치료외，환진행기타치료여려과술、청광안벌식입술、첩상체냉응혹광응급시망막광응，차구성차이무통계학의의（P>0.05）。대2조환자치료전후적안압화시력진행통계학분석。결과항VEGF조여대조조치료후안압균유명현하강。항VEGF조자（49.35±12.57） mm Hg（1 mm Hg=0.133 kPa）하강지（14.6±7.29） mm Hg；대조조자（52.34±10.67） mm Hg하강지（17.1±6.93） mm Hg。2조치료후1주지치료후3개월각시점안압지간비교，차이균무통계학의의（P>0.05）。항VEGF조여대조조치료후시력차이무통계학의의（P>0.05）。결론항VEGF능구억제홍막급시망막상신생혈관적생성화발전，단재신생혈관성청광안적치료중，상무법명현지개선예후。
OBJECTIVE To evaluate the affection of the anti-VEGF in the treatment of neovascular glauco-ma. METHODS 58cases (63 eyes), 40 males and 18 females, with average age of 65.81±14.68, were selected and been separated into two groups by weather got the Lucentis intraocular injection. No significant different between the two groups of the cases that get other treatment methods like trabeculactomy, glaucoma valve implantation, cy-clocryotherapy, cyclophotocoagulation or pan retinal photocoagulation. Intraocular pressure (IOP) and visual acurity (VS) before and after the combine treatment were been evaluated. RESULTS The IOP declined dramatically in both anti-VEGF group and control group. The IOP drops from (49.35±12.57) mm Hg (1 mm Hg=0.133 kPa) to (14.6±7.29) mm Hg in anti-VEGF group, but no significant different was seen among the post-treatment groups (P>0.05). The IOP drops from (52.34±10.67) mm Hg to (17.1±6.93) mm Hg in control group, no significant different was seen among the post-treatment groups too (P>0.05), and no significant different was seen between treatment group and no-treatment group at any time point (P>0.05). There was no significant different was seen in VS too (P>0.05). CONCLUSIONS Anti-VEGF treatment could control the happen and develop of the neovascularazation of iris and retinal effectively, but could not improve the prognosis of neovascular glaucoma.