CAJ | 학술논문

目的总结大疱性类天疱疮的临床、组织病理学特点、实验室检查及治疗经验。方法回顾性分析68例大疱性类天疱疮住院患者的临床资料。结果68例患者典型皮疹表现为在红斑或正常皮肤上出现紧张性水疱或大疱,也可见靶形红斑、环形水疱等多形性损害。皮肤组织病理学和直接免疫荧光检查可明确诊断。糖皮质激素控制皮损的初始剂量和最大剂量,在中度患者平均值分别为相当于泼尼松(48.26±12.23)mg/d和(63.27±9.70)mg/d,在重度患者平均值分别为(62.25±17.38)mg/d和(65.25±20.14)mg/d。结论中老年患者皮肤出现紧张性水疱或大疱,应考虑大疱性类天疱疮,需进行组织病理学和直接免疫荧光检查以明确诊断。治疗首选糖皮质激素,根据皮疹严重程度确定剂量,注重治疗的个体差异。
목적총결대포성류천포창적림상、조직병이학특점、실험실검사급치료경험。방법회고성분석68례대포성류천포창주원환자적림상자료。결과68례환자전형피진표현위재홍반혹정상피부상출현긴장성수포혹대포,야가견파형홍반、배형수포등다형성손해。피부조직병이학화직접면역형광검사가명학진단。당피질격소공제피손적초시제량화최대제량,재중도환자평균치분별위상당우발니송(48.26±12.23)mg/d화(63.27±9.70)mg/d,재중도환자평균치분별위(62.25±17.38)mg/d화(65.25±20.14)mg/d。결론중노년환자피부출현긴장성수포혹대포,응고필대포성류천포창,수진행조직병이학화직접면역형광검사이명학진단。치료수선당피질격소,근거피진엄중정도학정제량,주중치료적개체차이。
Objective To analyze and summarize the clinical and histopathologic features, laboratory testing and treatment experience of bullous pemphigoid ( BP) . Method Various clinical parameters were analyzed retrospective-ly in 68 hospitalised patients with BP. Result The male-female ratio was 1:1. 06. The average age of onset was (64. 24±8. 22) years old. The typical skin lesions characterized by tense vesicles or bullas on normal skin or an er-ythematous base. Various cutaneous lesions such as target erythema and annular blisters could be seen. The his-topathological and direct immunofluorescence examination could make a definite diagnosis. The initial and maximum corticosteroid dosage were(48. 26±12. 23) mg/d and (63. 27±9. 70) mg/d on patients with moderate BP while (62. 25±17. 38)mg/d and (65. 25±20. 14) mg/d with severe BP respectively. Conclusion The elderly patients with tense blisters in the skin, bullous pemphigoid should be considered. The histopathological and direct immuno-fluorescence examination can provide reliable evidence for diagnosis of BP. As the preferred treatment of choice, glucocorticoid should be different for individuals.