CAJ | 학술논문

目的评估帕瑞昔布钠联合马来酸氟吡汀对常规开胸肺叶切除术后镇痛的临床效果。方法选择常规开胸肺叶切除术后患者80例,随机分为帕瑞昔布钠联合马来酸氟吡汀组( A组,40例)及帕瑞昔布钠组(B组,40例)。两组术毕均给予帕瑞昔布钠40mg静脉注射,8小时/次,A组术后24小时后给予口服马来酸氟吡汀100mg,8小时/次。观察并记录：患者术后12、24、32、40、48、56、64、72小时的静息状态下视觉模拟评分( VAS),患者术后12、24、36、48、72小时的Ramsay镇静评分( RSS),以及药物不良反应情况。结果两组患者术前基本资料差异无显著性(P>0.05)；A组术后32、40、48、56、64、72小时的静息VAS评分比B组降低,而术后24、36、48小时的镇静评分比B组高,差异均存在显著性(P<0.05)；两组不良反应发生率差异无显著性。结论帕瑞昔布钠与马来酸氟吡汀联合应用符合多模式镇痛,可降低常规开胸肺叶切除术后患者的疼痛值,并有良好的镇静效果,同时无明显不良反应。
목적평고파서석포납연합마래산불필정대상규개흉폐협절제술후진통적림상효과。방법선택상규개흉폐협절제술후환자80례,수궤분위파서석포납연합마래산불필정조( A조,40례)급파서석포납조(B조,40례)。량조술필균급여파서석포납40mg정맥주사,8소시/차,A조술후24소시후급여구복마래산불필정100mg,8소시/차。관찰병기록：환자술후12、24、32、40、48、56、64、72소시적정식상태하시각모의평분( VAS),환자술후12、24、36、48、72소시적Ramsay진정평분( RSS),이급약물불량반응정황。결과량조환자술전기본자료차이무현저성(P>0.05)；A조술후32、40、48、56、64、72소시적정식VAS평분비B조강저,이술후24、36、48소시적진정평분비B조고,차이균존재현저성(P<0.05)；량조불량반응발생솔차이무현저성。결론파서석포납여마래산불필정연합응용부합다모식진통,가강저상규개흉폐협절제술후환자적동통치,병유량호적진정효과,동시무명현불량반응。
Objective To investigate the analgesic effect of parecoxib sodium and flupirtine maleate for postoperative pain after pulmonary lobectomy. Method Eighty patients undergoing pulmonary lobectomy were randomly divided in-to 2 groups( n=40 each):parecoxib group( group A) ,parecoxib and flupirtine maleate group( group B) . All the pa-tients were received parecoxib sodium for analgesia at the first 24h after surgery with frequency 40mg /8h. Patients in group A were taken the flupirtine maleate 3 times a day with 100mg. The visual analogue score(VAS) was recor-ded at 12,24,32,40,48,56,64,72 hours after surgery. Meanwhile the Ramsay sedation score(RSS) were recorded at 12,24,36,48,72 hours after surgery, the adverse effects related to analgesia were recorded. Result Compared with group B,the VAS values were decreased in group A at 12,24,32,40,48,56, 64 hours after surgery,while the RSS increased at 24,36 and 48 hours after surgery,all the difference is statistics significant with P<0. 05. No serious adverse effects occurred between the two groups and the difference was statistics means. Conclusion The combintion use of parecoxib sodium with flupirtine maleate was effective to the maleate for postoperative pain after pulmonary lo-bectomy which was occurred to the multimodal analgesia( MMA) . It also enhance the sedation effect without serious adverse effects.