CAJ | 학술논문

目的评价体外射频热疗联合腹腔内化疗治疗恶性腹水临床疗效、生活质量及其毒副作用。方法对68例恶性腹水患者随机分为实验组(34例)和对照组(34例),实验组为腹腔灌注化疗后即行体外射频热疗,对照组仅行腹腔灌注化疗,腹腔置管引流腹水后给予顺铂60mg腹腔灌注化疗,第1天、第5天,3周为1周期,2周期后评定疗效。结果试验组有效24例,有效率为70.6%,对照组有效15例,有效率为44.1%,差异有显著性(P<0.05)；实验组生活质量Karnofsky评分高于对照组,差异有显著性(P<0.05)；实验组血液毒副反应、胃肠道反应与对照组比较,差异无显著性(P>0.05)。结论体外射频热疗联合腹腔内灌注化疗治疗恶性腹水疗效好,提高生活质量,安全性高。
목적평개체외사빈열료연합복강내화료치료악성복수림상료효、생활질량급기독부작용。방법대68례악성복수환자수궤분위실험조(34례)화대조조(34례),실험조위복강관주화료후즉행체외사빈열료,대조조부행복강관주화료,복강치관인류복수후급여순박60mg복강관주화료,제1천、제5천,3주위1주기,2주기후평정료효。결과시험조유효24례,유효솔위70.6%,대조조유효15례,유효솔위44.1%,차이유현저성(P<0.05)；실험조생활질량Karnofsky평분고우대조조,차이유현저성(P<0.05)；실험조혈액독부반응、위장도반응여대조조비교,차이무현저성(P>0.05)。결론체외사빈열료연합복강내관주화료치료악성복수료효호,제고생활질량,안전성고。
Objective To evaluate the efficacy, life quality and toxic effects of treating malignant ascites with vitrora-diofrequency thermotherapy combinedintraperitoneal perfusion chemotherapy. Method 68 patients with malignant ascites wererandomly divided into experimentalgroup and control group,with 34 case in each group. The experimen-tal group received a treatment of vitro radiofrequency thermotherapy combinedintraperitoneal perfusion chemothera-py,the control group received a treatment of intraperitoneal chemotherapy. abdominal cavity was put Tube Drain-ascites, All patients were treated with cisplatin 60mg, The first day, the fifth day and three weeks constituted a cy-cle, and the effects were evaluated after two cycles. Result The effectivenessof experimental groupwas 24 cases, ef-fective rate was 70. 6%;The effectivenessof control group was 15 cases, effective rate was 44. 1%, and the differ-ence was significant(P<0. 05). The quality of life as shown by Karnofsky score in experimental group was higher than that in the control group, and the difference was significant(P<0. 05). The toxic effects on blood and digestive tract in the two groups were almost the same(P>0. 05). Conclusion The effects of treating malignant ascites with vitro radiofrequency thermotherapy combinedintraperitoneal perfusion chemotherapy was promotion,improve quality of life,higher safety .