国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2015年
10期
728-731
,共4页
非小细胞肺癌%多西他赛%顺铂%临床疗效
非小細胞肺癌%多西他賽%順鉑%臨床療效
비소세포폐암%다서타새%순박%림상료효
Non-small cell lung cancer%Docetaxel%Cis-platinum%Clinical efficacy
目的：观察多西他赛注射液联合顺铂治疗非小细胞肺癌(NSCLC)的疗效和安全性。方法选取我院收治的经病理组织学确诊的Ⅲ/Ⅳ期 NSCLC 患者136例,随机分成研究组和对照组,各68例,对照组给予多西他赛单药治疗,研究组采用多西他赛联合顺铂方案治疗。评估治疗2个周期后的治疗效果及不良反应发生情况。结果治疗2个周期后,研究组总有效率高于对照组(67.6% vs 47.1%,χ2=5.892,P =0.015),研究组患者白细胞减少、血小板降低、血清转氨酶上升的发生率明显高于对照组(χ2值分别为15.070、19.608、7.863,P 值均<0.05)；但两组患者恶心呕吐、腹泻、脱发和乏力不良反应发生率差异无统计学意义(P 值均>0.05)。结论多西他赛注射液联合顺铂对晚期 NSCLC 患者的治疗效果较好,血液毒性略增高,但可以耐受,可以考虑在临床应用。
目的：觀察多西他賽註射液聯閤順鉑治療非小細胞肺癌(NSCLC)的療效和安全性。方法選取我院收治的經病理組織學確診的Ⅲ/Ⅳ期 NSCLC 患者136例,隨機分成研究組和對照組,各68例,對照組給予多西他賽單藥治療,研究組採用多西他賽聯閤順鉑方案治療。評估治療2箇週期後的治療效果及不良反應髮生情況。結果治療2箇週期後,研究組總有效率高于對照組(67.6% vs 47.1%,χ2=5.892,P =0.015),研究組患者白細胞減少、血小闆降低、血清轉氨酶上升的髮生率明顯高于對照組(χ2值分彆為15.070、19.608、7.863,P 值均<0.05)；但兩組患者噁心嘔吐、腹瀉、脫髮和乏力不良反應髮生率差異無統計學意義(P 值均>0.05)。結論多西他賽註射液聯閤順鉑對晚期 NSCLC 患者的治療效果較好,血液毒性略增高,但可以耐受,可以攷慮在臨床應用。
목적：관찰다서타새주사액연합순박치료비소세포폐암(NSCLC)적료효화안전성。방법선취아원수치적경병리조직학학진적Ⅲ/Ⅳ기 NSCLC 환자136례,수궤분성연구조화대조조,각68례,대조조급여다서타새단약치료,연구조채용다서타새연합순박방안치료。평고치료2개주기후적치료효과급불량반응발생정황。결과치료2개주기후,연구조총유효솔고우대조조(67.6% vs 47.1%,χ2=5.892,P =0.015),연구조환자백세포감소、혈소판강저、혈청전안매상승적발생솔명현고우대조조(χ2치분별위15.070、19.608、7.863,P 치균<0.05)；단량조환자악심구토、복사、탈발화핍력불량반응발생솔차이무통계학의의(P 치균>0.05)。결론다서타새주사액연합순박대만기 NSCLC 환자적치료효과교호,혈액독성략증고,단가이내수,가이고필재림상응용。
Objective To investigate the clinical efficacy of docetaxel combined with cis-platinum in treatment of non-small cell lung cancer (NSCLC).Methods 136 NSCLC patients with phase Ⅲ-Ⅳdiagnosed by histopathology in our hospital were divided into research group and control group,68 cases each group.The patients in control group were treated with docetaxel while the research group was treated with docetaxel and cis-platinum.After two circle treatment,the clinical efficacy and adverse reactions were evaluated in the two groups.Results After two cycle treatment,the total efficiency rate of the research group was higher than that of the control group (67.6% vs 47.1%,χ2 = 5.892,P = 0.01 5 ).The incidence rates of decreased neutropenia,decreased thrombocytopenia,and increased serum transaminases in the research group were higher than those in the control group (χ2 = 1 5.070,1 9.608,7.863 respectively,all P <0.05).There was no statistical significance in the incidence rates of nausea,vomiting, diarrhea,and hair loss between the two groups (all P >0.05).Conclusions The programme of docetaxel injection combined with cisplatin is effective in the treatment of patients with advanced NSCLC,blood toxicity is slightly high but can be tolerated.It should be considered in clinical applications.
