CAJ | 학술논문

目的：探讨慢性阻塞性肺疾病（COPD）患者血清及痰中白介素-16、IFN - r 水平相关性及临床意义。方法：采用酶联免疫吸附试验（ELISA）检测 COPD 急性加重期、稳定期及健康对照组血清及痰中 IL -16、IFN - r 水平。结果：血清及痰液中 COPD急性加重期患者 IL -16、IFN - r 水平均明显高于稳定期及健康对照组，且稳定期血清 IL -16水平明显高于健康对照组，差异具有统计学意义（（p ﹤0.05）。在血清和痰液中 IL -16与 IFN - r 水平呈正相关性（r ＝0.630、0.594，p ﹤0.01）。结论：在 COPD 气道炎症中，IL -16、IFN - r 共同参与了炎症发病过程，二者联合检测对 COPD 患者病情程度判断有一定意义。
목적：탐토만성조새성폐질병（COPD）환자혈청급담중백개소-16、IFN - r 수평상관성급림상의의。방법：채용매련면역흡부시험（ELISA）검측 COPD 급성가중기、은정기급건강대조조혈청급담중 IL -16、IFN - r 수평。결과：혈청급담액중 COPD급성가중기환자 IL -16、IFN - r 수평균명현고우은정기급건강대조조，차은정기혈청 IL -16수평명현고우건강대조조，차이구유통계학의의（（p ﹤0.05）。재혈청화담액중 IL -16여 IFN - r 수평정정상관성（r ＝0.630、0.594，p ﹤0.01）。결론：재 COPD 기도염증중，IL -16、IFN - r 공동삼여료염증발병과정，이자연합검측대 COPD 환자병정정도판단유일정의의。
Objective Ti investigate the clinical significance and cirrelatiin between the serum if patients with chrinic ibstructive pul-minary disease(COPD)interleukin -16,IFN - r. Method Using enzyme - linked immunisirbent assay ti detect acute aggravating periid if COPD,stability and healthy cintrils in serum and sputum IL -16、IFN - r. Results In serum and sputum COPD patients with acute aggra-vating periid if IL - 16,IFN - r levels were significantly higher than that if stability and the healthy cintrils,and the level if serum IL -16 in stability significantly was higher than healthy cintrils. In serum and sputum there was a pisitively cirrelatiin with IFN - r and IL -16 level(r =0. 630、0. 594,p ﹤0. 01). Conclusion IL - 16、IFN - r are invilved in the pathigenesis if COPD airway inflammatiin pricess,and have a certain significance if jiinting detectiin judgment in the severity if COPD patients.