CAJ | 학술논문

目的：检测糖尿病足（DF）患者血清脂蛋白（a）[Lp（a）]和半胱氨酸蛋白酶抑制剂C（Cys C）水平，分析两指标与DF湿热毒盛证和脾肾阳虚、经脉不通证两种证型的关系。方法选择DF湿热毒盛证患者139例（ A组），DF脾肾阳虚、经脉不通证患者46例（B组）和单纯T2DM患者78例（C组）。采集空腹静脉血，测定各组血清Lp（a）、Cys C，并对结果进行分析。结果各组血清Lp（a）、Cys C水平比较，A、B组高于C组，B组高于A组，P＜0．05或＜0．01。单因素Logistic回归分析显示，Lp（a）和Cys C是DF脾肾阳虚、经脉不通证的危险因素（P均＜0．05）；多因素Logistic回归分析显示，Lp（a）为DF脾肾阳虚、经脉不通证的独立危险因素（P＜0．05）。结论 DF患者血清Lp（a）和Cys C水平显著升高，Lp（ a）和Cys C可能参与了DF脾肾阳虚、经脉不通证患者大血管病变的发生、发展。
목적：검측당뇨병족（DF）환자혈청지단백（a）[Lp（a）]화반광안산단백매억제제C（Cys C）수평，분석량지표여DF습열독성증화비신양허、경맥불통증량충증형적관계。방법선택DF습열독성증환자139례（ A조），DF비신양허、경맥불통증환자46례（B조）화단순T2DM환자78례（C조）。채집공복정맥혈，측정각조혈청Lp（a）、Cys C，병대결과진행분석。결과각조혈청Lp（a）、Cys C수평비교，A、B조고우C조，B조고우A조，P＜0．05혹＜0．01。단인소Logistic회귀분석현시，Lp（a）화Cys C시DF비신양허、경맥불통증적위험인소（P균＜0．05）；다인소Logistic회귀분석현시，Lp（a）위DF비신양허、경맥불통증적독립위험인소（P＜0．05）。결론 DF환자혈청Lp（a）화Cys C수평현저승고，Lp（ a）화Cys C가능삼여료DF비신양허、경맥불통증환자대혈관병변적발생、발전。
Objective To detect the levels of lipoprotein ( a) [ Lp( a) ] and cysteine proteinase inhibitor C ( Cys C) in serum of patients with diabetic foot (DF), and to analyze the correlations of two indicators with dampness-heat type, yang deficiency of spleen and kidney combined with meridian barrier type .Methods A total of 139 patients with damp-ness-heat type ( group A ) , 46 patients with yang deficiency of spleen and kidney combined with meridian barrier type (group B) and 78 patients with type 2 diabetes mellitus (T2DM) (group C) were enrolled.Fasting blood were collected for the determinations of Lp(a) and Cys C.The results were analyzed statistically.Results The levels of Lp(a) and Cys C in the group A and group B were significantly higher than those in the group C , and two indicators in the group B were significantly higher than those in the group A (P<0.01 or P<0.05).Univariate Logistic regression analysis showed that Lp( a) and Cys C were risk factors for yang deficiency of spleen and kidney combined with meridian barrier type of DF ( all P<0.05).Multivariate Logistic regression analysis showed that Lp (a) was the independent risk factor for yang deficiency of spleen and kidney combined with meridian barrier type of DF (P<0.05).Conclusions The Lp(a) and Cys C levels in the serum are significantly increased in DF patients , which indicates that Lp ( a) and Cys C may participate in the occur-rence and development of microangiopathy of DF patients with yang deficiency of spleen and kidney combined with meridian barrier type .