CAJ | 학술논문

内质网应激（ ERS）是内质网腔内错误折叠蛋白聚积的一种适应性反应。越来越多的证据表明，ERS可能是糖尿病肾病进展的重要机制之一。在糖尿病肾病的发展过程中，细胞内适宜的ERS作用可保护肾脏细胞免受高血糖等危险因素的损害，而程度过强或时间过长的ERS使细胞的保护机制不能与损伤作用抗衡，细胞内错误折叠的蛋白质在内质网中不断聚集，扰乱内质网的正常功能，从而使多个下游的细胞信号相关通路启动，诱导细胞凋亡发生，肾脏细胞不断死亡促进糖尿病肾病的进展。因此，ERS在糖尿病及其并发症脏器损害过程中的作用值得进一步研究。
내질망응격（ ERS）시내질망강내착오절첩단백취적적일충괄응성반응。월래월다적증거표명，ERS가능시당뇨병신병진전적중요궤제지일。재당뇨병신병적발전과정중，세포내괄의적ERS작용가보호신장세포면수고혈당등위험인소적손해，이정도과강혹시간과장적ERS사세포적보호궤제불능여손상작용항형，세포내착오절첩적단백질재내질망중불단취집，우란내질망적정상공능，종이사다개하유적세포신호상관통로계동，유도세포조망발생，신장세포불단사망촉진당뇨병신병적진전。인차，ERS재당뇨병급기병발증장기손해과정중적작용치득진일보연구。
Endoplasmic reticulum stress( ERS) is an adaptive response to the accumulation of misfolded proteins in the endoplasmic reticulum.In recent years,increasing evidences have shown that ERS plays an important role in diabetic nephropathy.In the progression of diabetic nephropathy,moderate ERS can protect renal cells from being harmed by risk factors such as high blood sugar,but the activation of unfolded protein response can enhance the progress of diabetic nephropathy,while excessive and prolonged ERS triggers cell apoptosis through disturbing the functions of the endoplasmic reticulum .These unfolded proteins aggregated in the endoplasmic reticulum can disturb the function of endoplasmic reticulum and trigger some related cellular signal pathways in down stream,and finally results in apoptosis which promotes the progress of dia-betic kidney disease.Therefore,the role of ERS in both diabetes and its complications should be further explored.