CAJ | 학술논문

随着糖尿病患病人数骤增、严重并发症及较高的致残率和致死率，2型糖尿病已成为重要的慢性病之一。肥胖、遗传和环境因素被认为是2型糖尿病的主要发病因素，其与外周组织胰岛素抵抗和脂肪组织炎症状态的发展紧密相关。肥胖者体内的炎症反应与传统炎症反应不同，其在2型糖尿病的发展中具有双重作用。该文对代谢性炎症反应及其特征、炎症反应相关的胰岛素抵抗机制及抗炎治疗新进展进行简要综述，以期为糖尿病的早期诊治提供参考。
수착당뇨병환병인수취증、엄중병발증급교고적치잔솔화치사솔，2형당뇨병이성위중요적만성병지일。비반、유전화배경인소피인위시2형당뇨병적주요발병인소，기여외주조직이도소저항화지방조직염증상태적발전긴밀상관。비반자체내적염증반응여전통염증반응불동，기재2형당뇨병적발전중구유쌍중작용。해문대대사성염증반응급기특정、염증반응상관적이도소저항궤제급항염치료신진전진행간요종술，이기위당뇨병적조기진치제공삼고。
With the increasing in the number of diabetes,severe complications,higher morbidity and mortality,type 2 diabetes mellitus( T2DM) has become one of the most important chronic diseases.Obesity, genetic and environmental factors have been considered as major importance in T2DM development, which is closely correlated with development of insulin resistance in peripheral tissues and adipose tissue inflammation state.Inflammatory response in obesity individuals is different from classical inflammation ,which has a dual role in the development of T2DM.Here is to make a review of the metabolic inflammation and its characteris-tics,IR mechanism and new advances in anti-inflammatory treatment for insulin resistance,so as to provide references for the early diagnosis and treatment of diabetes.