CAJ | 학술논문

胰岛β细胞功能受损是2型糖尿病发病的重要基础。多项研究发现提示，Wnt／β联蛋白经典信号通路通过直接或者与胰高血糖素样肽1、炎症通路等相互作用的方式对胰岛β细胞的新生、增殖及其功能发挥重要的调控作用，且可能介导了外周组织与β细胞的对话机制。对该通路及其调节分子在胰岛β细胞中的作用机制的深入探讨有助于为2型糖尿病的治疗提供新的思路和方向。
이도β세포공능수손시2형당뇨병발병적중요기출。다항연구발현제시，Wnt／β련단백경전신호통로통과직접혹자여이고혈당소양태1、염증통로등상호작용적방식대이도β세포적신생、증식급기공능발휘중요적조공작용，차가능개도료외주조직여β세포적대화궤제。대해통로급기조절분자재이도β세포중적작용궤제적심입탐토유조우위2형당뇨병적치료제공신적사로화방향。
Islet βcell dysfunction is the fundamental factor in the pathogenesis of type 2 diabetes.Multi-ple researches have implicated that the canonical Wnt/β-catenin signaling pathway may have significant effect on islet βcell neogenesis, proliferation and its function by direct or indirect interaction with glucagon-like peptide or inflammatory pathway.Also this pathway might possibly mediate the cross-talk betweenβcell and peripheral tissues.The in-depth research on canonical Wnt/β-catenin signaling pathway and its modula-tors′effect on the function of islet βcells can provide new directions for type 2 diabetes therapy.